Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4212963..4213551 Replicon chromosome
Accession NZ_CP024676
Organism Citrobacter pasteurii strain UMH17

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CUC49_RS20565 Protein ID WP_048213960.1
Coordinates 4213234..4213551 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag CUC49_RS20560 Protein ID WP_121585314.1
Coordinates 4212963..4213241 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC49_RS20550 4210470..4212101 + 1632 WP_121585313.1 Na/Pi cotransporter family protein -
CUC49_RS20555 4212163..4212852 - 690 WP_032942056.1 dipeptidase PepE -
CUC49_RS20560 4212963..4213241 - 279 WP_121585314.1 putative addiction module antidote protein Antitoxin
CUC49_RS20565 4213234..4213551 - 318 WP_048213960.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUC49_RS20570 4213744..4214037 + 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
CUC49_RS20575 4214037..4214354 + 318 WP_003841409.1 CcdB family protein -
CUC49_RS20580 4214388..4215200 - 813 WP_121585315.1 shikimate 5-dehydrogenase -
CUC49_RS20585 4215202..4216425 - 1224 WP_121585316.1 L-sorbose 1-phosphate reductase -
CUC49_RS20590 4216494..4217318 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CUC49_RS20595 4217330..4218127 - 798 WP_044715019.1 PTS mannose/fructose/sorbose transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11998.87 Da        Isoelectric Point: 9.8851

>T88275 WP_048213960.1 NZ_CP024676:c4213551-4213234 [Citrobacter pasteurii]
IMEILQTTVFQRWEQNLRDRRAKTLIAARLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQHGCRIIILLCGGDKS
SQANDITLAKVLARSLDYQETFRHE

Download         Length: 318 bp

>T88275 NZ_CP024676:c4213551-4213234 [Citrobacter pasteurii]
ATCATGGAAATTCTTCAGACCACGGTTTTCCAACGCTGGGAACAGAATCTGCGAGATCGCAGGGCCAAAACGCTCATTGC
CGCACGACTTTTTCGACTGGCGAATGGTTTAGCTGGCGATGTTAAACCTGTAGGTGAAGGTATCAGCGAAATGCGCATTT
CTTACGGTCCTGGTTACAGGATTTACTTTAAACAGCATGGCTGCCGCATCATCATTTTGCTATGTGGTGGCGATAAAAGC
TCACAAGCCAACGATATCACCCTTGCAAAAGTGCTCGCCCGTTCACTGGATTATCAGGAGACCTTCCGCCATGAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9836.41 Da        Isoelectric Point: 5.0807

>AT88275 WP_121585314.1 NZ_CP024676:c4213241-4212963 [Citrobacter pasteurii]
MNKLTQYDPAAALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMASIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKVLGIELTLKK

Download         Length: 279 bp

>AT88275 NZ_CP024676:c4213241-4212963 [Citrobacter pasteurii]
ATGAATAAGCTTACTCAGTACGATCCCGCTGCTGCGCTAGTTGATGATGAAGAAATTGCTGTATTTATGGCGGATGCCCT
CGAAACAGGCGATGCAACGTACATTGCAAAAGCATTGGGCGTGGTGGCTCGCGCTAAGGGAATGGCGAGCATCGCGGCAG
AAACGGGATTATCCCGCGAGCAGCTTTATCGCTCTTTTAGTGAGAAAGGTAATCCGACGCTGAAAACCACGCTTGCAGTG
ATGAAGGTACTCGGCATTGAATTGACACTAAAAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References