Detailed information of TA system TA088272

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3048243..3048897
• Replicon: chromosome
• Accession: NZ_CP024676
• Organism: Citrobacter pasteurii strain UMH17

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CUC49_RS14740
• Protein ID: WP_048213165.1
• Coordinates: 3048243..3048650 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A6N6K0R3
• Locus tag: CUC49_RS14745
• Protein ID: WP_005123351.1
• Coordinates: 3048631..3048897 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUC49_RS14720	3044144..3045877	-	1734	WP_121585021.1	single-stranded-DNA-specific exonuclease RecJ	-
CUC49_RS14725	3045883..3046596	-	714	WP_121585022.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
CUC49_RS14730	3046620..3047516	-	897	WP_005123354.1	site-specific tyrosine recombinase XerD	-
CUC49_RS14735	3047630..3048151	+	522	WP_048213164.1	flavodoxin FldB	-
CUC49_RS14740	3048243..3048650	-	408	WP_048213165.1	protein YgfX	Toxin
CUC49_RS14745	3048631..3048897	-	267	WP_005123351.1	FAD assembly factor SdhE	Antitoxin
CUC49_RS14750	3049153..3050133	+	981	WP_048213166.1	tRNA-modifying protein YgfZ	-
CUC49_RS14755	3050224..3050883	-	660	WP_003026947.1	hemolysin III family protein	-
CUC49_RS14760	3051047..3051358	-	312	WP_048213167.1	N(4)-acetylcytidine aminohydrolase	-
CUC49_RS14765	3051411..3052139	+	729	WP_003838265.1	MurR/RpiR family transcriptional regulator	-
CUC49_RS14770	3052260..3053693	+	1434	WP_121585023.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15940.86 Da
• Isoelectric Point: 10.9468

>T88272 WP_048213165.1 NZ_CP024676:c3048650-3048243 [Citrobacter pasteurii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVCAPWMIKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQQVKQG

Nucleotide

• Length: 408 bp

>T88272 NZ_CP024676:c3048650-3048243 [Citrobacter pasteurii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCACAGTGGCTCTCTCTGCTCATTCATGGGCTGGTTGCGGT
ATTCATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGTTGGTGCTGCTCTCTCTGGTGGTGTTTGATAGCG
TACGCAGTCAGCGTCGCATTAACGCTTGTCAGGGAGAGATTAGACTGTTAATGGACGGTCGCCTGCGCTGGCAGGGGCAA
GAGTGGTCTATCGTTTGTGCACCCTGGATGATTAAAACGGGCATGATGCTGCGTTTGCGTTCAGATGCGGGAAAACGTCA
GCATTTGTGGCTGGCAGCGGACAGCATGGATGACGCTGAGTGGCGGGATTTGCGGCGGTTAATGCTGCAACAGGTAAAGC
AGGGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10642.16 Da
• Isoelectric Point: 5.1700

>AT88272 WP_005123351.1 NZ_CP024676:c3048897-3048631 [Citrobacter pasteurii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT88272 NZ_CP024676:c3048897-3048631 [Citrobacter pasteurii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTGGACATCTCTATCATGCCGTT
TTTCGAACATGAGTATGACAACTTAAGTGACGAAGAAAAACGCATCTTTATCCGTCTGCTGGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGAGCAGTTGGAGCAGATGGTGCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6N6K0R3