Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 454451..455071 Replicon chromosome
Accession NZ_CP024676
Organism Citrobacter pasteurii strain UMH17

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CUC49_RS02090 Protein ID WP_002892050.1
Coordinates 454451..454669 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag CUC49_RS02095 Protein ID WP_003021733.1
Coordinates 454697..455071 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC49_RS02055 449800..450411 + 612 WP_121584303.1 hypothetical protein -
CUC49_RS02060 450494..450847 + 354 WP_061067436.1 DUF1428 family protein -
CUC49_RS02065 450902..452455 - 1554 WP_048212413.1 EAL domain-containing protein -
CUC49_RS02070 452644..452904 + 261 WP_005125189.1 type B 50S ribosomal protein L31 -
CUC49_RS02075 452906..453046 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
CUC49_RS02080 453124..453594 - 471 WP_040232692.1 YlaC family protein -
CUC49_RS02085 453711..454262 - 552 WP_115600829.1 maltose O-acetyltransferase -
CUC49_RS02090 454451..454669 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CUC49_RS02095 454697..455071 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
CUC49_RS02100 455560..458709 - 3150 WP_048212411.1 efflux RND transporter permease AcrB -
CUC49_RS02105 458732..459925 - 1194 WP_048212410.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T88263 WP_002892050.1 NZ_CP024676:c454669-454451 [Citrobacter pasteurii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T88263 NZ_CP024676:c454669-454451 [Citrobacter pasteurii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGCTGTCAAACAATTGACACGCTTGAACGTGT
TATTGAGAAAAATAAATATGAATTGTCTGACAATGAACTGGCTGTATTTTACTCAGCCGCCGATCATCGTCTTGCTGAAT
TGACAATGAATAAGCTCTACGACAAGATCCCAACATCTGTTTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT88263 WP_003021733.1 NZ_CP024676:c455071-454697 [Citrobacter pasteurii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT88263 NZ_CP024676:c455071-454697 [Citrobacter pasteurii]
ATGGATGAATACTCACCGAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGCAATCATGGTTGGGTAAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATTGATGAATACCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGTATTAATACGCAGGATCTACAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTCAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References