Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4899565..4901115 Replicon chromosome
Accession NZ_CP024675
Organism Citrobacter werkmanii strain UMH18

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CUC50_RS23815 Protein ID WP_121529900.1
Coordinates 4899820..4901115 (+) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CUC50_RS23810 Protein ID WP_032942207.1
Coordinates 4899565..4899816 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC50_RS23800 4895697..4897382 + 1686 WP_121529898.1 integrase arm-type DNA-binding domain-containing protein -
CUC50_RS23805 4897630..4898658 - 1029 WP_121529899.1 RelA/SpoT domain-containing protein -
CUC50_RS23810 4899565..4899816 + 252 WP_032942207.1 helix-turn-helix domain-containing protein Antitoxin
CUC50_RS23815 4899820..4901115 + 1296 WP_121529900.1 type II toxin-antitoxin system HipA family toxin Toxin
CUC50_RS23820 4901203..4901469 + 267 WP_023302770.1 hypothetical protein -
CUC50_RS23825 4901581..4902234 + 654 WP_058656242.1 HNH endonuclease -
CUC50_RS23830 4902290..4903879 - 1590 WP_121529901.1 TraI domain-containing protein -
CUC50_RS23835 4904050..4904985 + 936 WP_153070618.1 erythromycin esterase family protein -
CUC50_RS23840 4905012..4905383 - 372 WP_009652327.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4895454..4960336 64882


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 49174.58 Da        Isoelectric Point: 7.0101

>T88262 WP_121529900.1 NZ_CP024675:4899820-4901115 [Citrobacter werkmanii]
VEKLTVALNGIIVGTLEKTAGGEMSFYYQRDWLERAGSRAISLSMPLREERYRGEIVYNFFDNLLPDSEQIRSRIQARFH
APTKQPFDLLARIGMDCVGAIQLWPYETDIPSIQRVDAEPLTENEIEHLLQGYKDAPLGMQAEVDDFRISLAGAQEKTAL
FWWNNRWCRPRGSTPTSHIFKLPIGYIANNGIDLRESVENEWLCSKIAAEFGFPVADTRVAYFGQQKILIVERFDRRWAK
DGQWLMRLPTEDFCQALGVAPALKYESDGGPGIARSMDLLLGSQQPLEDRILFFRSQIFFWMLAAIDGHAKNFSVFLEPN
SAYRMAPLYDVMSAYPLMHPKGIPPRKAKMAMALSGRNRHFHWSTIMPRHFLSTAREVSFPVLQVEQLLAEMKQRTESVI
SKVETMLPAGFPEHISEAIFKGLRHQSACIP

Download         Length: 1296 bp

>T88262 NZ_CP024675:4899820-4901115 [Citrobacter werkmanii]
GTGGAAAAATTAACGGTTGCGCTTAATGGCATCATTGTTGGTACGCTGGAGAAAACAGCGGGCGGGGAAATGTCTTTTTA
CTACCAAAGAGACTGGCTGGAAAGAGCCGGTTCTCGTGCTATTTCTCTTTCGATGCCGTTACGGGAAGAGCGTTATCGTG
GCGAAATAGTTTATAACTTTTTTGATAATCTTCTGCCAGATAGCGAGCAAATTCGTAGCCGGATTCAGGCGCGGTTCCAT
GCGCCCACAAAGCAACCTTTCGACTTGTTAGCACGTATTGGGATGGACTGTGTTGGGGCTATACAGCTTTGGCCTTATGA
AACCGATATTCCATCTATTCAGAGAGTGGATGCCGAACCCTTAACTGAAAACGAAATAGAACATCTGCTGCAGGGATACA
AAGATGCCCCATTGGGTATGCAGGCAGAGGTCGATGATTTCCGTATTTCACTGGCGGGTGCACAGGAAAAAACAGCTCTG
TTCTGGTGGAATAATCGATGGTGCAGGCCACGCGGGAGCACACCGACAAGCCATATTTTTAAACTACCTATTGGCTATAT
CGCCAATAACGGAATTGACCTTCGCGAGAGCGTTGAAAATGAGTGGCTGTGTTCAAAAATAGCGGCTGAGTTTGGTTTTC
CCGTTGCGGATACCCGAGTTGCGTATTTTGGGCAACAAAAGATACTGATTGTTGAACGTTTCGATCGGCGATGGGCTAAA
GATGGTCAATGGCTGATGCGTTTGCCAACGGAAGACTTTTGTCAGGCATTGGGCGTGGCTCCGGCACTTAAGTATGAATC
TGATGGTGGGCCAGGAATCGCCAGAAGCATGGATTTGTTACTGGGTTCTCAACAACCTCTTGAGGACAGGATTTTGTTTT
TCAGAAGTCAGATCTTTTTCTGGATGTTGGCGGCAATTGATGGCCATGCCAAAAACTTCAGTGTATTCCTTGAACCAAAC
AGCGCTTACCGTATGGCCCCGCTTTACGATGTAATGTCTGCTTACCCTTTGATGCACCCGAAAGGTATTCCTCCCAGAAA
AGCTAAAATGGCGATGGCGCTATCCGGACGTAATCGCCATTTTCACTGGAGTACAATCATGCCCCGTCATTTTCTTTCCA
CTGCGCGAGAAGTGAGCTTTCCCGTTTTGCAAGTTGAGCAATTGCTGGCGGAGATGAAACAACGAACTGAATCGGTGATC
TCAAAAGTGGAAACGATGTTACCTGCAGGATTCCCGGAGCACATAAGCGAAGCTATTTTTAAAGGATTAAGGCATCAGTC
AGCGTGTATTCCGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9522.81 Da        Isoelectric Point: 9.9484

>AT88262 WP_032942207.1 NZ_CP024675:4899565-4899816 [Citrobacter werkmanii]
MNVTSPKMLAQAVRDARKQRKLTQRETAESMSMKQSTVSEFENHPEGTRLDTLFKLLAALDLELQVVSRKGKNKSSEGWD
QEW

Download         Length: 252 bp

>AT88262 NZ_CP024675:4899565-4899816 [Citrobacter werkmanii]
ATGAACGTAACCTCACCCAAAATGCTGGCTCAGGCAGTCAGGGATGCACGTAAGCAACGTAAGCTGACTCAACGCGAAAC
TGCGGAAAGTATGAGCATGAAGCAATCAACGGTTTCTGAGTTTGAGAACCATCCGGAGGGGACACGGCTGGACACGCTTT
TTAAGCTCCTTGCCGCACTGGATCTTGAGCTTCAGGTTGTAAGCCGGAAGGGTAAAAACAAATCATCTGAGGGTTGGGAC
CAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References