88245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4548734..4549400 Replicon chromosome
Accession NZ_CP024673
Organism Citrobacter freundii strain UMH19

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag CUC51_RS22605 Protein ID WP_071696338.1
Coordinates 4548734..4549093 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag CUC51_RS22610 Protein ID WP_071696337.1
Coordinates 4549083..4549400 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC51_RS22595 4546134..4547765 + 1632 WP_003031618.1 Na/Pi cotransporter family protein -
CUC51_RS22600 4547831..4548520 - 690 WP_003841421.1 dipeptidase PepE -
CUC51_RS22605 4548734..4549093 + 360 WP_071696338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUC51_RS22610 4549083..4549400 + 318 WP_071696337.1 helix-turn-helix domain-containing protein Antitoxin
CUC51_RS22615 4549410..4549688 - 279 WP_008324306.1 putative addiction module antidote protein -
CUC51_RS22620 4549596..4549928 + 333 WP_071696336.1 hypothetical protein -
CUC51_RS22625 4549973..4550785 - 813 WP_071696335.1 shikimate 5-dehydrogenase -
CUC51_RS22630 4550787..4552010 - 1224 WP_071696334.1 L-sorbose 1-phosphate reductase -
CUC51_RS22635 4552078..4552902 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
CUC51_RS22640 4552914..4553711 - 798 WP_003841402.1 PTS mannose/fructose/sorbose transporter subunit IIC -
CUC51_RS22645 4553777..4554271 - 495 WP_003031646.1 mannose/fructose/sorbose PTS transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13491.50 Da        Isoelectric Point: 10.1224

>T88245 WP_071696338.1 NZ_CP024673:4548734-4549093 [Citrobacter freundii]
MTKPLYWVGHAWKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNTWRAVYTIQLKNAVYVL
HVFQKKSVAGKATPKPEIDLIYQRIKAAQRHAQESGYVT

Download         Length: 360 bp

>T88245 NZ_CP024673:4548734-4549093 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCATGCCTGGAAAGATCTACAGGGAATGCCAGAACATGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGCGCGGGGGTTC
TGGAAGTCGTTGAGGATTATCACGGCAACACCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTGCCGGGAAGGCAACGCCCAAACCTGAAATTGACCTGATTTATCAGCGGATCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11494.41 Da        Isoelectric Point: 9.0005

>AT88245 WP_071696337.1 NZ_CP024673:4549083-4549400 [Citrobacter freundii]
MSHEVEASSGNVYADLGVYDAEQMQLKAQLAMVIGEILQRKGLTQQQSAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp

>AT88245 NZ_CP024673:4549083-4549400 [Citrobacter freundii]
ATGTCACATGAAGTTGAAGCCAGTAGCGGAAATGTTTACGCCGATTTAGGCGTGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAACTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGTCCGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGCTACGTGGTCAGTTTCGTGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGGCTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References