Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3937799..3938430 Replicon chromosome
Accession NZ_CP024673
Organism Citrobacter freundii strain UMH19

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag CUC51_RS19600 Protein ID WP_003837806.1
Coordinates 3938155..3938430 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag CUC51_RS19595 Protein ID WP_003837808.1
Coordinates 3937799..3938158 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC51_RS19570 3933485..3934042 + 558 WP_003837816.1 DcrB family lipoprotein -
CUC51_RS19575 3934046..3935263 - 1218 WP_071696361.1 MFS transporter -
CUC51_RS19580 3935545..3936594 + 1050 WP_003023393.1 AI-2E family transporter -
CUC51_RS19585 3936657..3937235 + 579 WP_061547458.1 4'-phosphopantetheinyl transferase AcpT -
CUC51_RS19590 3937285..3937686 + 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
CUC51_RS19595 3937799..3938158 - 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CUC51_RS19600 3938155..3938430 - 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
CUC51_RS19605 3938508..3939632 - 1125 WP_048213609.1 ABC transporter permease -
CUC51_RS19610 3939632..3942379 - 2748 WP_048218800.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T88243 WP_003837806.1 NZ_CP024673:c3938430-3938155 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

>T88243 NZ_CP024673:c3938430-3938155 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT88243 WP_003837808.1 NZ_CP024673:c3938158-3937799 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT88243 NZ_CP024673:c3938158-3937799 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTGATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References