Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3290475..3291129 Replicon chromosome
Accession NZ_CP024673
Organism Citrobacter freundii strain UMH19

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag CUC51_RS16305 Protein ID WP_003026936.1
Coordinates 3290475..3290882 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag CUC51_RS16310 Protein ID WP_003026938.1
Coordinates 3290863..3291129 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC51_RS16285 3286423..3288156 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
CUC51_RS16290 3288162..3288875 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CUC51_RS16295 3288899..3289795 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
CUC51_RS16300 3289909..3290430 + 522 WP_003026933.1 flavodoxin FldB -
CUC51_RS16305 3290475..3290882 - 408 WP_003026936.1 protein YgfX Toxin
CUC51_RS16310 3290863..3291129 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
CUC51_RS16320 3291386..3292366 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
CUC51_RS16325 3292460..3293119 - 660 WP_071697472.1 hemolysin III family protein -
CUC51_RS16330 3293282..3293593 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
CUC51_RS16335 3293646..3294374 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
CUC51_RS16340 3294496..3295929 + 1434 WP_071697473.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T88241 WP_003026936.1 NZ_CP024673:c3290882-3290475 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T88241 NZ_CP024673:c3290882-3290475 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTAGGCTGTTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT88241 WP_003026938.1 NZ_CP024673:c3291129-3290863 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT88241 NZ_CP024673:c3291129-3290863 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAGCGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References