Detailed information of TA system TA088138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 3554327..3554858
• Replicon: chromosome
• Accession: NZ_CP024644
• Organism: Komagataeibacter xylinus strain xylinus

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CT154_RS16300
• Protein ID: WP_039998565.1
• Coordinates: 3554327..3554626 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CT154_RS16305
• Protein ID: WP_202795779.1
• Coordinates: 3554613..3554858 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CT154_RS16260	3549569..3550621	-	1053	WP_034929753.1	IS110 family transposase	-
CT154_RS16670	3550690..3551166	-	477	WP_157772024.1	hypothetical protein	-
CT154_RS16270	3551174..3551329	+	156	Protein_3164	DUF736 family protein	-
CT154_RS16280	3551547..3551828	+	282	Protein_3165	conjugal transfer protein TrbF	-
CT154_RS16285	3551825..3552826	+	1002	WP_039998564.1	P-type conjugative transfer protein TrbG	-
CT154_RS16290	3552823..3554031	+	1209	WP_007397368.1	TrbI/VirB10 family protein	-
CT154_RS16295	3554028..3554300	+	273	WP_007397369.1	DUF2274 domain-containing protein	-
CT154_RS16300	3554327..3554626	-	300	WP_039998565.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CT154_RS16305	3554613..3554858	-	246	WP_202795779.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CT154_RS16675	3555132..3555896	-	765	WP_139064266.1	hypothetical protein	-
CT154_RS16310	3556044..3556874	+	831	WP_039998273.1	IS5-like element IS1032 family transposase	-
CT154_RS16680	3556876..3557472	-	597	WP_139064267.1	hypothetical protein	-
CT154_RS16685	3557469..3559004	-	1536	WP_139064268.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3545074..3559004	13930
	-	flank	IS/Tn	-	-	3549569..3550642	1073
	-	flank	IS/Tn	-	-	3556044..3556874	830

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-92)

Antitoxin

• Antitoxin ParD (1-67)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11703.42 Da
• Isoelectric Point: 6.8441

>T88138 WP_039998565.1 NZ_CP024644:c3554626-3554327 [Komagataeibacter xylinus]
MPTCRKTRLAEDDIVNIYMQGVRDFGPRQAEIYHAGLSDAFDLIASHPQLAPERHEFDPPIRLHRHRAHHILYLIDDDGV
LIVRVLPRLRRWERLMETD

Nucleotide

• Length: 300 bp

>T88138 NZ_CP024644:c3554626-3554327 [Komagataeibacter xylinus]
ATGCCGACCTGTAGAAAGACACGGCTCGCCGAAGACGACATCGTCAACATCTATATGCAGGGCGTGAGGGATTTCGGGCC
GCGGCAGGCCGAAATCTACCATGCAGGGCTGTCGGACGCGTTCGACCTTATCGCCTCACATCCGCAGCTTGCGCCTGAAC
GTCACGAATTCGACCCACCGATACGGCTGCACCGTCATCGGGCTCACCATATCCTCTATCTCATTGACGACGATGGGGTT
CTGATCGTCCGCGTGCTGCCCCGACTACGGCGCTGGGAGCGGCTTATGGAAACAGACTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8883.87 Da
• Isoelectric Point: 6.4618

>AT88138 WP_202795779.1 NZ_CP024644:c3554858-3554613 [Komagataeibacter xylinus]
MNVSLPDPMKEWVEAQAKTGRYSNASDYVRDLIRRDQEARAAHDEVQAHITAGLRSGVGTRSMKQLLQDARAAAGTTDAD
L

Nucleotide

• Length: 246 bp

>AT88138 NZ_CP024644:c3554858-3554613 [Komagataeibacter xylinus]
ATGAACGTATCCCTGCCCGATCCCATGAAGGAATGGGTAGAGGCTCAGGCCAAAACGGGACGCTACAGCAATGCAAGCGA
CTATGTCCGCGACCTGATCCGGCGTGATCAGGAGGCCCGTGCGGCGCATGATGAGGTTCAGGCCCACATCACGGCCGGTC
TGCGTAGTGGCGTCGGGACCAGGAGCATGAAGCAGTTGCTGCAGGATGCTCGCGCGGCTGCCGGGACGACGGATGCCGAC
CTGTAG