Detailed information of TA system TA088137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2487306..2487847
• Replicon: chromosome
• Accession: NZ_CP024644
• Organism: Komagataeibacter xylinus strain xylinus

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CT154_RS11315
• Protein ID: WP_202795781.1
• Coordinates: 2487545..2487847 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A181C5T9
• Locus tag: CT154_RS11310
• Protein ID: WP_039998678.1
• Coordinates: 2487306..2487548 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CT154_RS11290	2482808..2483827	+	1020	WP_007397859.1	cytochrome d ubiquinol oxidase subunit II	-
CT154_RS11295	2483814..2483963	+	150	WP_007397858.1	DUF2474 domain-containing protein	-
CT154_RS11305	2485351..2486697	-	1347	Protein_2222	AAA family ATPase	-
CT154_RS11310	2487306..2487548	+	243	WP_039998678.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CT154_RS11315	2487545..2487847	+	303	WP_202795781.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2436465..2533405	96940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11434.00 Da
• Isoelectric Point: 7.3581

>T88137 WP_202795781.1 NZ_CP024644:2487545-2487847 [Komagataeibacter xylinus]
VMRFLLRPAAQADLSAIWDYSAQRWGTTQADDYVRAIGRACQDLADGTRHGRTADDIREGYLKMLVGSHLLFFRVNENGF
IDVIRILHGRMDPTRHMTDV

Nucleotide

• Length: 303 bp

>T88137 NZ_CP024644:2487545-2487847 [Komagataeibacter xylinus]
GTGATGCGTTTCCTTTTAAGGCCAGCAGCTCAAGCCGATCTTTCAGCAATCTGGGATTATTCAGCACAACGATGGGGAAC
CACTCAGGCCGATGACTATGTTCGAGCTATTGGGCGAGCCTGTCAGGATCTTGCGGACGGAACACGGCATGGACGGACTG
CCGACGATATTCGGGAAGGGTATCTCAAGATGCTCGTCGGCTCTCATCTGCTTTTTTTTCGGGTAAACGAGAATGGCTTT
ATCGACGTAATCCGCATCCTGCACGGGCGTATGGACCCCACACGCCATATGACGGATGTCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8829.82 Da
• Isoelectric Point: 4.7962

>AT88137 WP_039998678.1 NZ_CP024644:2487306-2487548 [Komagataeibacter xylinus]
MARNTSISLGDHFADFVDQQVKGGRYGSASDVVRAGLRILEERETRLETLRSALIDGEQSGAAEPFDIEDFLAAKAKQFR

Nucleotide

• Length: 243 bp

>AT88137 NZ_CP024644:2487306-2487548 [Komagataeibacter xylinus]
ATGGCACGCAACACATCAATCTCACTCGGTGACCATTTTGCAGACTTCGTAGACCAGCAGGTAAAAGGTGGACGCTACGG
CTCAGCGAGCGACGTCGTACGCGCTGGTCTGCGGATTCTTGAAGAGCGGGAGACACGACTTGAAACTCTCCGCTCTGCCC
TGATCGACGGCGAGCAATCCGGTGCAGCCGAGCCGTTCGATATAGAAGATTTCCTCGCCGCGAAGGCTAAACAGTTCCGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A181C5T9