Detailed information of TA system TA088136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2470362..2470912
• Replicon: chromosome
• Accession: NZ_CP024644
• Organism: Komagataeibacter xylinus strain xylinus

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7JII7
• Locus tag: CT154_RS11225
• Protein ID: WP_003618711.1
• Coordinates: 2470362..2470655 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5QDQ9
• Locus tag: CT154_RS11230
• Protein ID: WP_003618686.1
• Coordinates: 2470652..2470912 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CT154_RS11205	2466308..2467006	+	699	WP_039998713.1	arsenical resistance protein ArsH	-
CT154_RS11210	2467015..2468070	+	1056	WP_007397880.1	NAD(P)/FAD-dependent oxidoreductase	-
CT154_RS11215	2468285..2468968	-	684	WP_007397879.1	DUF1275 domain-containing protein	-
CT154_RS11220	2468968..2470230	-	1263	WP_007397878.1	sodium:proton antiporter	-
CT154_RS11225	2470362..2470655	-	294	WP_003618711.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CT154_RS11230	2470652..2470912	-	261	WP_003618686.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CT154_RS11235	2471232..2472059	-	828	WP_010510580.1	S-formylglutathione hydrolase	-
CT154_RS11240	2472084..2472485	-	402	WP_099963253.1	VOC family protein	-
CT154_RS11245	2472545..2473654	-	1110	WP_010510585.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
CT154_RS11250	2473696..2473971	-	276	WP_010510587.1	formaldehyde-responsive transcriptional repressor FrmR	-
CT154_RS11255	2474329..2474691	-	363	WP_010510588.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2436465..2533405	96940

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11605.35 Da
• Isoelectric Point: 7.9998

>T88136 WP_003618711.1 NZ_CP024644:c2470655-2470362 [Komagataeibacter xylinus]
MKEYCLEFDDRALREWDALDGSVRKKFEKKLEKLIWNPHSPGNELHRDLSGFYKIKLLKDGYRLVYQVIDERIVIYVIAV
GRRADNEIYELASKRTE

Nucleotide

• Length: 294 bp

>T88136 NZ_CP024644:c2470655-2470362 [Komagataeibacter xylinus]
ATGAAAGAGTATTGTCTTGAATTCGACGACAGAGCACTCAGAGAGTGGGATGCTCTTGACGGCAGCGTGCGTAAGAAATT
TGAAAAGAAGCTGGAAAAGCTGATCTGGAACCCTCACTCTCCAGGAAACGAACTGCATCGCGACCTATCAGGGTTTTATA
AGATCAAGCTTCTGAAAGATGGTTACCGCCTTGTTTATCAGGTCATCGACGAACGGATCGTCATCTATGTAATTGCCGTT
GGCCGGAGAGCCGATAATGAGATTTATGAACTGGCTTCGAAGCGAACAGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9762.23 Da
• Isoelectric Point: 10.4645

>AT88136 WP_003618686.1 NZ_CP024644:c2470912-2470652 [Komagataeibacter xylinus]
MSAVTFRVDETLKAAAVKKLSAQGISLSDALRDTLAYIAETGRSPVKRRLVTDEDAELIEIVRERLKNPAQKHRMTFAEL
KNRHRE

Nucleotide

• Length: 261 bp

>AT88136 NZ_CP024644:c2470912-2470652 [Komagataeibacter xylinus]
ATGTCTGCTGTTACATTCCGGGTAGATGAAACGCTGAAGGCAGCCGCAGTTAAGAAGTTGTCGGCTCAAGGCATTTCACT
TTCTGACGCACTGCGCGATACGCTCGCGTATATTGCTGAAACGGGTCGCTCTCCCGTCAAGCGGAGGCTTGTCACAGACG
AGGATGCGGAGCTTATCGAGATTGTGCGCGAACGCCTAAAAAACCCTGCCCAAAAGCATCGTATGACTTTTGCAGAGCTT
AAGAACCGTCATCGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A6N3T9M6