Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2118332..2118962 Replicon chromosome
Accession NZ_CP024634
Organism Bathymodiolus thermophilus thioautotrophic gill symbiont strain EPR9N

Toxin (Protein)


Gene name vapC Uniprot ID A0A1J5TTE6
Locus tag MS2017_RS07405 Protein ID WP_071564942.1
Coordinates 2118332..2118730 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1J5TTE4
Locus tag MS2017_RS07410 Protein ID WP_071564941.1
Coordinates 2118723..2118962 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS2017_RS07380 2113482..2114126 - 645 WP_071564947.1 rhodanese-like domain-containing protein -
MS2017_RS07385 2114215..2114445 - 231 WP_071564946.1 hypothetical protein -
MS2017_RS07390 2114531..2114974 - 444 WP_071564945.1 ribonuclease HI -
MS2017_RS07395 2114967..2116727 - 1761 WP_071564944.1 N-acetylglutaminylglutamine amidotransferase -
MS2017_RS07400 2116783..2118174 + 1392 WP_122951786.1 3-isopropylmalate dehydratase large subunit -
MS2017_RS07405 2118332..2118730 - 399 WP_071564942.1 tRNA(fMet)-specific endonuclease VapC Toxin
MS2017_RS07410 2118723..2118962 - 240 WP_071564941.1 antitoxin Antitoxin
MS2017_RS07420 2119236..2120915 + 1680 WP_122952240.1 DUF262 domain-containing HNH endonuclease family protein -
MS2017_RS07425 2120908..2121522 + 615 WP_071564938.1 3-isopropylmalate dehydratase small subunit -
MS2017_RS07430 2121519..2122103 + 585 WP_071564937.1 Holliday junction branch migration protein RuvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15045.37 Da        Isoelectric Point: 6.9786

>T88120 WP_071564942.1 NZ_CP024634:c2118730-2118332 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
MNKYLLDTNICIYVMKRKPIDLLEIFNENAGQMAISSITLSELIHGVEKSQQQKNNRLILEDFVSHLNVLDYTQKSAQQY
GIIRADLEKKGVIIGVNDLHIAGHSISEGLILVTNNEKEFKRVHGLKVENWV

Download         Length: 399 bp

>T88120 NZ_CP024634:c2118730-2118332 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
ATGAATAAATATTTATTGGATACCAATATTTGTATTTATGTAATGAAGCGTAAACCTATTGATTTGCTTGAAATTTTTAA
TGAAAATGCAGGGCAAATGGCAATTTCTAGTATTACTTTATCTGAACTTATTCATGGGGTGGAAAAATCTCAACAACAAA
AGAATAATCGACTTATTCTTGAAGATTTTGTTTCACATTTAAATGTCCTTGATTACACGCAAAAATCCGCTCAACAATAT
GGCATTATTAGAGCGGATTTAGAGAAAAAAGGTGTCATAATAGGCGTTAATGATTTGCATATTGCAGGGCATTCAATAAG
TGAAGGCTTGATTCTGGTTACGAATAATGAAAAAGAATTTAAGCGTGTTCACGGTTTAAAAGTTGAAAATTGGGTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9157.46 Da        Isoelectric Point: 5.0322

>AT88120 WP_071564941.1 NZ_CP024634:c2118962-2118723 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
MITSSVFLNNKTQAVRLPMAMRLDSSVKKVFIRKNNKDRIISPIDSVWDNFFLSDAQVSDDFLVTRAVQLECERESFDE

Download         Length: 240 bp

>AT88120 NZ_CP024634:c2118962-2118723 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
ATGATAACTAGTTCGGTATTTCTTAACAACAAAACTCAGGCAGTCAGATTGCCAATGGCTATGCGTTTGGACAGTTCGGT
TAAAAAAGTGTTTATTCGTAAAAATAATAAAGACAGGATTATATCGCCAATTGACAGTGTTTGGGACAATTTTTTTCTCT
CGGATGCCCAAGTTAGCGATGATTTTTTAGTCACAAGAGCGGTGCAGTTGGAGTGTGAAAGGGAATCGTTTGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J5TTE6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J5TTE4

References