Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 915655..916283 Replicon chromosome
Accession NZ_CP024634
Organism Bathymodiolus thermophilus thioautotrophic gill symbiont strain EPR9N

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MS2017_RS03350 Protein ID WP_122951260.1
Coordinates 915882..916283 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MS2017_RS03345 Protein ID WP_122951259.1
Coordinates 915655..915885 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS2017_RS03335 911270..913627 + 2358 WP_122951257.1 VWA domain-containing protein -
MS2017_RS03340 913631..915220 + 1590 WP_122951258.1 RNA-directed DNA polymerase -
MS2017_RS03345 915655..915885 + 231 WP_122951259.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MS2017_RS03350 915882..916283 + 402 WP_122951260.1 type II toxin-antitoxin system VapC family toxin Toxin
MS2017_RS03355 916283..916537 + 255 WP_071565086.1 hypothetical protein -
MS2017_RS03360 916541..917419 + 879 WP_122951261.1 tetratricopeptide repeat protein -
MS2017_RS03365 917660..918993 + 1334 Protein_669 IS5 family transposase -
MS2017_RS03370 919242..920324 - 1083 WP_122951262.1 trypsin-like serine protease -
MS2017_RS03375 920566..921114 - 549 WP_122951263.1 molybdopterin adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(6-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15100.53 Da        Isoelectric Point: 6.7293

>T88119 WP_122951260.1 NZ_CP024634:915882-916283 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
MIYMLDTNIISYLIKSHDEMLVRKFEVVSQYDLVVISSISVAELRYGVKKKQSKNLETVVNNFLHPLEQKDFDESSAIIY
GDIRVDLEKRGRVIGALDMLIAAHAKSLGATIVTNNTKEFDRVVGLKVENWVV

Download         Length: 402 bp

>T88119 NZ_CP024634:915882-916283 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
TTGATTTATATGTTGGACACCAATATTATTTCTTATTTGATTAAAAGTCATGATGAGATGTTGGTGCGTAAATTTGAGGT
GGTGTCGCAGTATGATTTGGTTGTGATTTCTTCTATTAGTGTTGCTGAATTGCGTTATGGTGTGAAGAAAAAGCAATCAA
AAAACTTAGAAACGGTTGTTAATAATTTTTTACATCCGCTTGAACAAAAAGACTTTGATGAATCATCGGCAATTATTTAT
GGGGATATTCGTGTTGATTTGGAAAAACGAGGTAGGGTTATTGGTGCGTTGGATATGTTAATTGCCGCACATGCAAAAAG
TTTAGGCGCTACTATTGTTACTAACAACACTAAAGAGTTTGATAGGGTTGTGGGTTTGAAGGTGGAAAATTGGGTGGTAT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8893.12 Da        Isoelectric Point: 4.7420

>AT88119 WP_122951259.1 NZ_CP024634:915655-915885 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
MLAKVFQSGNSQAVRLPKAMRFDVSEVEIERVGESLVLTPYKKPDWQKMSDALDQFKALDFEFDRNQPQQIRDDLF

Download         Length: 231 bp

>AT88119 NZ_CP024634:915655-915885 [Bathymodiolus thermophilus thioautotrophic gill symbiont]
ATGTTAGCAAAAGTATTTCAATCAGGTAATTCTCAGGCGGTGCGTTTGCCTAAGGCGATGCGGTTTGATGTAAGTGAGGT
GGAGATTGAACGAGTGGGTGAGTCTTTGGTTTTAACGCCTTATAAAAAGCCAGATTGGCAAAAAATGAGTGATGCGTTGG
ATCAATTCAAGGCATTGGATTTTGAATTTGATAGAAATCAGCCGCAGCAAATTAGAGATGATTTGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References