Detailed information of TA system TA088118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2708686..2709361
• Replicon: chromosome
• Accession: NZ_CP024632
• Organism: Acinetobacter junii strain lzh-X15

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CS557_RS12640
• Protein ID: WP_099949173.1
• Coordinates: 2709182..2709361 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CS557_RS12635
• Protein ID: WP_099949172.1
• Coordinates: 2708686..2709102 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS557_RS12610	2704153..2704497	+	345	WP_099949169.1	phage tail assembly protein	-
CS557_RS12615	2704512..2704631	+	120	WP_099949524.1	GpE family phage tail protein	-
CS557_RS12620	2704628..2707210	+	2583	WP_099949170.1	phage tail tape measure protein	-
CS557_RS12625	2707221..2707628	+	408	WP_099949171.1	phage tail protein	-
CS557_RS12630	2707631..2708614	+	984	WP_099949525.1	hypothetical protein	-
CS557_RS12635	2708686..2709102	-	417	WP_099949172.1	antitoxin	Antitoxin
CS557_RS12640	2709182..2709361	-	180	WP_099949173.1	type II toxin-antitoxin system HicA family toxin	Toxin
CS557_RS12645	2709529..2709714	+	186	WP_099949174.1	hypothetical protein	-
CS557_RS15540	2709885..2710256	+	372	WP_157774471.1	hypothetical protein	-
CS557_RS12655	2710340..2711308	-	969	WP_157774472.1	hypothetical protein	-
CS557_RS15650	2711325..2712389	-	1065	WP_213064357.1	hypothetical protein	-
CS557_RS12665	2712979..2713173	+	195	WP_099949177.1	hypothetical protein	-
CS557_RS12670	2713170..2713349	+	180	WP_099949178.1	hypothetical protein	-
CS557_RS12675	2713346..2714023	+	678	WP_099949179.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2684561..2720926	36365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (14-79)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6934.09 Da
• Isoelectric Point: 10.9252

>T88118 WP_099949173.1 NZ_CP024632:c2709361-2709182 [Acinetobacter junii]
MSYSEFKRWLIEQGVIFVRRGKGSHWIIQLHDKRSVFPDHGSKEIPNGTRLKIKKDLGL

Nucleotide

• Length: 180 bp

>T88118 NZ_CP024632:c2709361-2709182 [Acinetobacter junii]
ATGAGCTATAGCGAGTTTAAACGGTGGCTCATTGAGCAAGGTGTGATCTTTGTAAGACGTGGTAAGGGATCACACTGGAT
TATACAGTTACATGATAAACGAAGTGTTTTTCCTGATCATGGTAGCAAAGAGATCCCCAATGGTACTCGTTTAAAGATCA
AAAAGGACTTGGGGCTTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15642.07 Da
• Isoelectric Point: 4.5917

>AT88118 WP_099949172.1 NZ_CP024632:c2709102-2708686 [Acinetobacter junii]
MKYAVQIVREDDAFVVSCRDLPQLNSVGYSLDEALTEALDGIETALMIYYMDGKKAIPLPSEALEGEHLIRLPAQVAVKI
ALYNEMLKQKITRAELGRRLDWKQAQVNRLWELDHSTKLEAIEAAFNAIDREIELIVA

Nucleotide

• Length: 417 bp

>AT88118 NZ_CP024632:c2709102-2708686 [Acinetobacter junii]
ATGAAATATGCAGTACAAATTGTTCGTGAAGACGATGCATTTGTAGTGTCTTGTCGTGATCTACCACAACTTAACAGCGT
TGGATATTCTTTGGATGAGGCATTAACCGAAGCCTTAGACGGAATTGAAACTGCTTTAATGATTTATTATATGGATGGTA
AAAAGGCGATTCCTTTACCATCTGAAGCACTTGAAGGTGAACATTTAATTCGTTTACCTGCCCAAGTTGCTGTAAAAATT
GCTTTATACAATGAGATGTTAAAGCAAAAAATCACTAGAGCTGAGTTAGGTCGTAGACTCGATTGGAAACAAGCGCAAGT
CAATCGTTTATGGGAATTAGATCATTCAACAAAATTGGAAGCGATCGAAGCCGCATTTAATGCAATTGATAGAGAAATCG
AGTTAATCGTTGCTTAA