88115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5117104..5117712 Replicon chromosome
Accession NZ_CP024630
Organism Pseudomonas aeruginosa strain PA59

Toxin (Protein)


Gene name PfiT Uniprot ID A0A3S4N9Q9
Locus tag CPZ93_RS24220 Protein ID WP_031672658.1
Coordinates 5117104..5117451 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag CPZ93_RS24225 Protein ID WP_003114155.1
Coordinates 5117461..5117712 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ93_RS24195 5113603..5114034 + 432 WP_031632963.1 hypothetical protein -
CPZ93_RS24200 5114723..5114911 + 189 Protein_4788 hypothetical protein -
CPZ93_RS24205 5114942..5115259 + 318 Protein_4789 hypothetical protein -
CPZ93_RS24210 5115371..5115577 + 207 WP_071534345.1 AlpA family phage regulatory protein -
CPZ93_RS24215 5115583..5116785 - 1203 WP_028680753.1 integrase family protein -
CPZ93_RS24220 5117104..5117451 - 348 WP_031672658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CPZ93_RS24225 5117461..5117712 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CPZ93_RS24230 5117926..5118909 - 984 WP_031672657.1 tyrosine-type recombinase/integrase -
CPZ93_RS24235 5118909..5120201 - 1293 WP_071659043.1 hypothetical protein -
CPZ93_RS24240 5120460..5121722 - 1263 WP_049290957.1 hypothetical protein -
CPZ93_RS24245 5121724..5122074 - 351 WP_003159569.1 DUF2523 domain-containing protein -
CPZ93_RS24250 5122084..5122692 - 609 WP_003163344.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5087198..5135420 48222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12898.69 Da        Isoelectric Point: 4.5143

>T88115 WP_031672658.1 NZ_CP024630:c5117451-5117104 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGAQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T88115 NZ_CP024630:c5117451-5117104 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGCACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT88115 WP_003114155.1 NZ_CP024630:c5117712-5117461 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT88115 NZ_CP024630:c5117712-5117461 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4N9Q9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References