Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2802774..2803816 Replicon chromosome
Accession NZ_CP024630
Organism Pseudomonas aeruginosa strain PA59

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CPZ93_RS13450 Protein ID WP_003109777.1
Coordinates 2803241..2803816 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag CPZ93_RS13445 Protein ID WP_003050245.1
Coordinates 2802774..2803244 (+) Length 157 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ93_RS13410 2798166..2799584 - 1419 WP_020924934.1 TIGR03752 family integrating conjugative element protein -
CPZ93_RS13415 2799574..2800485 - 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
CPZ93_RS13420 2800482..2801174 - 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
CPZ93_RS13425 2801171..2801569 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
CPZ93_RS13430 2801581..2801940 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
CPZ93_RS13435 2801957..2802190 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
CPZ93_RS13440 2802187..2802570 - 384 WP_003120001.1 RAQPRD family integrative conjugative element protein -
CPZ93_RS13445 2802774..2803244 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
CPZ93_RS13450 2803241..2803816 + 576 WP_003109777.1 PIN domain-containing protein Toxin
CPZ93_RS13455 2803834..2804748 + 915 WP_003105629.1 AAA family ATPase -
CPZ93_RS13460 2804745..2805215 + 471 WP_003105626.1 hypothetical protein -
CPZ93_RS13465 2805212..2805712 + 501 WP_003090159.1 hypothetical protein -
CPZ93_RS13470 2805712..2806614 + 903 WP_003105624.1 nucleotidyltransferase domain-containing protein -
CPZ93_RS13475 2806653..2807378 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2752381..2853347 100966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(9-114)

Antitoxin

(85-133)


Sequences


Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T88112 WP_003109777.1 NZ_CP024630:2803241-2803816 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T88112 NZ_CP024630:2803241-2803816 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAGGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT88112 WP_003050245.1 NZ_CP024630:2802774-2803244 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT88112 NZ_CP024630:2802774-2803244 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References