88110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142056..142561 Replicon chromosome
Accession NZ_CP024630
Organism Pseudomonas aeruginosa strain PA59

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag CPZ93_RS00640 Protein ID WP_003121619.1
Coordinates 142056..142337 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag CPZ93_RS00645 Protein ID WP_003112628.1
Coordinates 142334..142561 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ93_RS00615 137307..138656 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
CPZ93_RS00620 138705..139391 + 687 WP_003083762.1 FadR family transcriptional regulator -
CPZ93_RS00625 139492..140226 + 735 WP_003117208.1 GntR family transcriptional regulator -
CPZ93_RS00630 140430..140816 + 387 WP_014602345.1 aegerolysin family protein -
CPZ93_RS00635 140848..141756 - 909 WP_003083769.1 LysR family transcriptional regulator -
CPZ93_RS00640 142056..142337 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
CPZ93_RS00645 142334..142561 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
CPZ93_RS00650 142737..143357 - 621 WP_003101226.1 hypothetical protein -
CPZ93_RS00655 143458..143958 + 501 WP_003112629.1 LEA type 2 family protein -
CPZ93_RS00660 144031..144372 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CPZ93_RS00665 144454..145881 - 1428 WP_003121620.1 GABA permease -
CPZ93_RS00670 146050..147543 - 1494 WP_031653061.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T88110 WP_003121619.1 NZ_CP024630:c142337-142056 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T88110 NZ_CP024630:c142337-142056 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT88110 WP_003112628.1 NZ_CP024630:c142561-142334 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT88110 NZ_CP024630:c142561-142334 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References