Detailed information of TA system TA088109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1428107..1428652
• Replicon: chromosome
• Accession: NZ_CP024627
• Organism: Vibrio coralliilyticus strain SCSIO 43001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CTT30_RS06895
• Protein ID: WP_252036463.1
• Coordinates: 1428107..1428403 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7X8YLC8
• Locus tag: CTT30_RS06900
• Protein ID: WP_005526987.1
• Coordinates: 1428410..1428652 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTT30_RS06850 (CTT30_06885)	1423875..1424129	+	255	WP_252036457.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CTT30_RS06855 (CTT30_06890)	1424122..1424391	+	270	WP_252036458.1	Txe/YoeB family addiction module toxin	-
CTT30_RS06860	1424570..1424884	+	315	WP_252036459.1	hypothetical protein	-
CTT30_RS06865	1425441..1425593	+	153	WP_252036460.1	hypothetical protein	-
CTT30_RS06870 (CTT30_06900)	1425594..1426358	+	765	WP_252036619.1	PhzF family phenazine biosynthesis protein	-
CTT30_RS06875	1426376..1426465	+	90	WP_239871702.1	DUF3265 domain-containing protein	-
CTT30_RS06880 (CTT30_06910)	1426493..1426762	+	270	WP_252036461.1	hypothetical protein	-
CTT30_RS06885 (CTT30_06915)	1426907..1427326	+	420	WP_252036358.1	hypothetical protein	-
CTT30_RS06890 (CTT30_06920)	1427450..1427935	+	486	WP_252036462.1	GNAT family N-acetyltransferase	-
CTT30_RS06895 (CTT30_06925)	1428107..1428403	-	297	WP_252036463.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTT30_RS06900 (CTT30_06930)	1428410..1428652	-	243	WP_005526987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTT30_RS06910	1430471..1430614	+	144	WP_252036465.1	hypothetical protein	-
CTT30_RS06915	1430633..1430863	+	231	WP_252036466.1	hypothetical protein	-
CTT30_RS06920 (CTT30_06945)	1431085..1432425	-	1341	WP_252036467.1	BspA family leucine-rich repeat surface protein	-
CTT30_RS06925 (CTT30_06950)	1432464..1432901	-	438	WP_252036468.1	BspA family leucine-rich repeat surface protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1303146..1429994	126848
	-	inside	Integron	-	-	1302139..1428858	126719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11249.88 Da
• Isoelectric Point: 9.8450

>T88109 WP_252036463.1 NZ_CP024627:c1428403-1428107 [Vibrio coralliilyticus]
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T88109 NZ_CP024627:c1428403-1428107 [Vibrio coralliilyticus]
ATGCAAAAGAACAAATACAAACTGAGTAAATTAGCTCAGACTCATTTACGGAAAATCAAAAGCTATACTGTTAACAACTT
CTCCGAGACCCAGTGGCGAAGCTATAAAGATACGTTACTAACTGGTTTTCAAATGCTTGCTGATAATCCAGCTGTTGGTC
GCAGTTGTGATGACATATACCCAAGCGGGTTCTATTTCCCTGTGGGCAAGCATACCGCTTATTTTACAAAAGAGGATGGC
TTCATTTTAGTTGTAGCTATACTCGGTCAATCACAGCTTCCTCAGAACCACTTATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8974.16 Da
• Isoelectric Point: 4.7914

>AT88109 WP_005526987.1 NZ_CP024627:c1428652-1428410 [Vibrio coralliilyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT88109 NZ_CP024627:c1428652-1428410 [Vibrio coralliilyticus]
ATGCACACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGCTACTTCTAAGCGCCCAACGTGAGCCTGTGAAGAT
TAGCAAAAACAGTAAAGATGCCGTCGTTGTAATGTCTATCAAGGACTATGAAGAACTAGAAGCAATGAAAACCGATTACC
TTAAGCACTGTTTCGAGTCAGCGAAACAAGACTTAGCTCAAGGAAATGTGGTTGATGGTGAAGACTTTTTAAACGCCTTA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A7X8YLC8