Detailed information of TA system TA088104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1344232..1344777
• Replicon: chromosome
• Accession: NZ_CP024627
• Organism: Vibrio coralliilyticus strain SCSIO 43001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A151KUE6
• Locus tag: CTT30_RS06230
• Protein ID: WP_038939651.1
• Coordinates: 1344232..1344528 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CTT30_RS06235
• Protein ID: WP_239866745.1
• Coordinates: 1344535..1344777 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTT30_RS06185 (CTT30_06260)	1339343..1339693	+	351	WP_252036372.1	hypothetical protein	-
CTT30_RS06190 (CTT30_06265)	1340308..1340617	+	310	Protein_1187	DUF4144 domain-containing protein	-
CTT30_RS06195 (CTT30_06270)	1340760..1341257	+	498	WP_170966842.1	hypothetical protein	-
CTT30_RS06200 (CTT30_06275)	1341395..1341766	+	372	WP_252036373.1	RidA family protein	-
CTT30_RS06205 (CTT30_06280)	1341918..1342307	+	390	WP_252036374.1	hypothetical protein	-
CTT30_RS06210 (CTT30_06285)	1342451..1342906	-	456	WP_252036375.1	hypothetical protein	-
CTT30_RS06215 (CTT30_06290)	1342989..1343171	+	183	WP_252036376.1	hypothetical protein	-
CTT30_RS06220	1343513..1343653	+	141	WP_252036377.1	hypothetical protein	-
CTT30_RS06225 (CTT30_06295)	1343713..1344060	+	348	WP_239866754.1	hypothetical protein	-
CTT30_RS06230 (CTT30_06300)	1344232..1344528	-	297	WP_038939651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTT30_RS06235 (CTT30_06305)	1344535..1344777	-	243	WP_239866745.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTT30_RS06240 (CTT30_06310)	1345031..1345768	+	738	WP_239876928.1	SDR family oxidoreductase	-
CTT30_RS06245	1345746..1345883	+	138	WP_239876929.1	DUF3265 domain-containing protein	-
CTT30_RS06250 (CTT30_06315)	1347192..1347440	+	249	WP_252036378.1	hypothetical protein	-
CTT30_RS06255	1347669..1347905	+	237	WP_252036379.1	hypothetical protein	-
CTT30_RS06260 (CTT30_06320)	1348296..1348958	+	663	WP_252036380.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1303146..1429994	126848
	-	inside	Integron	-	-	1302139..1428858	126719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11278.93 Da
• Isoelectric Point: 9.6269

>T88104 WP_038939651.1 NZ_CP024627:c1344528-1344232 [Vibrio coralliilyticus]
MQKNKYKLSKLAQTHLQKIKNYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T88104 NZ_CP024627:c1344528-1344232 [Vibrio coralliilyticus]
ATGCAAAAGAATAAATATAAGCTAAGTAAATTAGCACAGACCCATTTACAAAAAATCAAAAACTATACCGTCAACAATTT
CTCTGAGATGCAATGGCGAAGCTACAAAGATACCTTACTAACAGGGTTTCAAATGCTTGCTGACAACCCGGCTGTTGGTC
GCAGTTGCGATGAGATATACCCAAGTGGTTTTTATTTCCCAGTGGGTAAGCATACCGCTTACTTTACAAAAGAAGATGGC
TTCATTTTAGTTGTTGCTGTACTCGGTCAATCACAACTTCCGCAGAACCACCTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9030.23 Da
• Isoelectric Point: 4.7914

>AT88104 WP_239866745.1 NZ_CP024627:c1344777-1344535 [Vibrio coralliilyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLVQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT88104 NZ_CP024627:c1344777-1344535 [Vibrio coralliilyticus]
ATGCACACATTAACAGCAAATGATGCCAAACGTAATTTTGGTGAGTTACTTCTGAGCGCTCAACGTGAGCCAGTGAAAAT
TAGCAAAAATAGCAAAGATGCCGTAGTAGTTATGTCGATTAAGGACTATGAAGAGCTGGAAGCAATGAAAACTGATTACC
TGAGACATTGTTTCGAGTCAGCTAAGCAAGACTTGGTACAAGGCAATGTGGTTGATGGTGAAGACTTTTTAAACGCCTTA
TAA

Structures

Toxin

• AlphaFold DB: A0A151KUE6