Detailed information of TA system TA088103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2734106..2734631
• Replicon: chromosome
• Accession: NZ_CP024621
• Organism: Halomonas meridiana strain SCSIO 43005

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CTT34_RS13120
• Protein ID: WP_159342819.1
• Coordinates: 2734106..2734390 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6F8XC30
• Locus tag: CTT34_RS13125
• Protein ID: WP_062372637.1
• Coordinates: 2734380..2734631 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTT34_RS13075	2729132..2729398	-	267	WP_159342812.1	Txe/YoeB family addiction module toxin	-
CTT34_RS13080	2729391..2729645	-	255	WP_159342813.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
CTT34_RS13085	2729728..2730063	-	336	WP_009100498.1	PhnA domain-containing protein	-
CTT34_RS13090	2730169..2730531	-	363	WP_153842707.1	helix-turn-helix transcriptional regulator	-
CTT34_RS13095	2730624..2730953	+	330	WP_159342814.1	nuclear transport factor 2 family protein	-
CTT34_RS13100	2730950..2731723	+	774	WP_159342815.1	SDR family oxidoreductase	-
CTT34_RS13105	2731809..2732777	+	969	WP_159342816.1	putative zinc-binding metallopeptidase	-
CTT34_RS13110	2732803..2733696	-	894	WP_159342817.1	dihydrodipicolinate synthase family protein	-
CTT34_RS13115	2733743..2734063	-	321	WP_159342818.1	hypothetical protein	-
CTT34_RS13120	2734106..2734390	-	285	WP_159342819.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTT34_RS13125	2734380..2734631	-	252	WP_062372637.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CTT34_RS13130	2734744..2735562	-	819	WP_159342820.1	tryptophan synthase subunit alpha	-
CTT34_RS13135	2735583..2736800	-	1218	WP_159342821.1	tryptophan synthase subunit beta	-
CTT34_RS13140	2736924..2737814	+	891	WP_159342822.1	LysR family transcriptional regulator	-
CTT34_RS13145	2737811..2738209	-	399	WP_159342823.1	VOC family protein	-
CTT34_RS13150	2738243..2738932	-	690	WP_159342824.1	VIT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11042.18 Da
• Isoelectric Point: 10.4966

>T88103 WP_159342819.1 NZ_CP024621:c2734390-2734106 [Halomonas meridiana]
MTYKLRFLPAALKEWEKLSPPVKQQFKKKLAERLETPRVLADKLSGFDACYKIKLRSVGYRLVYEVVDDELFIYVIAVGK
RDKGKVYASLKRRM

Nucleotide

• Length: 285 bp

>T88103 NZ_CP024621:c2734390-2734106 [Halomonas meridiana]
ATGACCTATAAGCTACGCTTTTTGCCCGCGGCCTTGAAAGAGTGGGAAAAGCTTAGCCCACCCGTCAAACAACAGTTCAA
AAAGAAGCTGGCTGAAAGGCTAGAAACCCCACGTGTGCTTGCCGATAAACTCAGTGGTTTCGATGCCTGCTATAAAATAA
AGCTTCGAAGCGTAGGCTATCGTCTGGTCTATGAAGTAGTGGATGATGAACTGTTTATCTACGTTATTGCTGTGGGTAAG
CGTGACAAAGGCAAAGTCTACGCGTCGCTAAAGCGCCGGATGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9159.51 Da
• Isoelectric Point: 4.5659

>AT88103 WP_062372637.1 NZ_CP024621:c2734631-2734380 [Halomonas meridiana]
MHQVLANFSVSISELKKNPSALLSQASGAPIAVLNHNKPAAYLVPVETYEAMMEMLEDYELAKLVEERRADKDKAVTVSL
DDL

Nucleotide

• Length: 252 bp

>AT88103 NZ_CP024621:c2734631-2734380 [Halomonas meridiana]
ATGCACCAAGTATTAGCTAACTTTTCGGTCAGTATTTCTGAGCTAAAGAAAAACCCTTCGGCACTGCTGAGCCAGGCAAG
CGGTGCCCCCATTGCTGTGTTGAATCACAACAAGCCCGCCGCTTACCTTGTCCCTGTAGAAACTTATGAGGCGATGATGG
AGATGCTGGAAGACTACGAGCTGGCCAAGCTAGTGGAAGAGCGTCGCGCCGATAAAGACAAGGCCGTCACGGTATCACTG
GATGACCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A6F8XC30