Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1076446..1077085 Replicon chromosome
Accession NZ_CP024621
Organism Halomonas meridiana strain SCSIO 43005

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CTT34_RS05285 Protein ID WP_159341509.1
Coordinates 1076903..1077085 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CTT34_RS05280 Protein ID WP_159341508.1
Coordinates 1076446..1076865 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTT34_RS05250 1072102..1073034 + 933 WP_159341502.1 hypothetical protein -
CTT34_RS05255 1073019..1073558 + 540 WP_159341503.1 hypothetical protein -
CTT34_RS05260 1073575..1074144 - 570 WP_159341504.1 hypothetical protein -
CTT34_RS05265 1074417..1074767 + 351 WP_159341505.1 hypothetical protein -
CTT34_RS05270 1075299..1075883 - 585 WP_159341506.1 DUF2335 domain-containing protein -
CTT34_RS05275 1075831..1076058 - 228 WP_159341507.1 hypothetical protein -
CTT34_RS05280 1076446..1076865 - 420 WP_159341508.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CTT34_RS05285 1076903..1077085 - 183 WP_159341509.1 type II toxin-antitoxin system HicA family toxin Toxin
CTT34_RS05290 1077170..1078156 - 987 WP_159341510.1 phage late control D family protein -
CTT34_RS05295 1078153..1078596 - 444 WP_159341511.1 phage tail protein -
CTT34_RS05300 1078607..1081699 - 3093 WP_159341512.1 phage tail tape measure protein -
CTT34_RS05305 1081721..1081864 - 144 WP_159341513.1 GpE family phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1064330..1101737 37407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6626.77 Da        Isoelectric Point: 11.4901

>T88101 WP_159341509.1 NZ_CP024621:c1077085-1076903 [Halomonas meridiana]
VNSRALIKQLEADGWALVRVKGSHHHFRHPTKPGTITVPHPKKDLKTGLVKAIRKSAGLE

Download         Length: 183 bp

>T88101 NZ_CP024621:c1077085-1076903 [Halomonas meridiana]
GTGAACAGCAGAGCACTGATCAAGCAATTGGAAGCGGATGGATGGGCACTAGTCAGAGTCAAAGGCAGCCACCACCACTT
CAGGCACCCGACCAAACCCGGCACCATCACCGTGCCACATCCGAAAAAGGATCTGAAAACGGGATTGGTCAAAGCCATCA
GGAAAAGCGCTGGCCTCGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15265.17 Da        Isoelectric Point: 4.4429

>AT88101 WP_159341508.1 NZ_CP024621:c1076865-1076446 [Halomonas meridiana]
MLFPIAIERGDEQHAYGVVVPDLPGCHSAGDTFEDALANAKEAIDGWLEVAVEYGDPIPEATSIEHHMDNPDFTGWIWAV
VDIDVTPYLGKSHKINVTLPDLLVKQIDDFVARHPGDKTRSGFLSRVAMAELARNKQAS

Download         Length: 420 bp

>AT88101 NZ_CP024621:c1076865-1076446 [Halomonas meridiana]
ATGTTATTTCCCATTGCCATTGAACGCGGCGACGAACAACACGCCTATGGCGTCGTGGTGCCCGACCTGCCCGGCTGCCA
CTCCGCAGGCGACACCTTCGAAGACGCCTTGGCCAACGCCAAAGAAGCCATCGATGGCTGGCTGGAAGTGGCCGTTGAAT
ACGGCGACCCCATCCCCGAAGCCACGTCCATCGAACATCACATGGACAACCCCGACTTCACCGGCTGGATCTGGGCCGTT
GTCGATATCGACGTGACCCCGTACCTGGGCAAAAGCCACAAGATCAACGTCACCCTGCCCGACCTCCTGGTCAAACAGAT
CGACGACTTCGTGGCCCGTCACCCCGGCGACAAAACCCGCTCCGGCTTTCTCTCCCGCGTCGCCATGGCCGAACTGGCCA
GGAACAAACAAGCCAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References