Detailed information of TA system TA088100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 978861..979363
• Replicon: chromosome
• Accession: NZ_CP024621
• Organism: Halomonas meridiana strain SCSIO 43005

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A857GIF8
• Locus tag: CTT34_RS04755
• Protein ID: WP_016914643.1
• Coordinates: 978861..979115 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CTT34_RS04760
• Protein ID: WP_159341419.1
• Coordinates: 979112..979363 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTT34_RS04715	973888..974388	+	501	WP_159341412.1	DUF4760 domain-containing protein	-
CTT34_RS04720	974385..974789	+	405	WP_159341413.1	hypothetical protein	-
CTT34_RS04725	974878..975333	+	456	WP_159341414.1	hypothetical protein	-
CTT34_RS04730	975354..976157	+	804	WP_159341415.1	hypothetical protein	-
CTT34_RS04735	976265..976684	+	420	WP_159341416.1	hypothetical protein	-
CTT34_RS04740	976868..977512	+	645	WP_159341417.1	DUF2971 domain-containing protein	-
CTT34_RS04750	978412..978789	+	378	WP_159341418.1	Ltp family lipoprotein	-
CTT34_RS04755	978861..979115	-	255	WP_016914643.1	Txe/YoeB family addiction module toxin	Toxin
CTT34_RS04760	979112..979363	-	252	WP_159341419.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CTT34_RS04765	979527..980348	-	822	WP_159341420.1	aldo/keto reductase	-
CTT34_RS04770	980547..981011	+	465	WP_159341421.1	OsmC family protein	-
CTT34_RS04775	981057..981644	+	588	WP_159341422.1	GNAT family N-acetyltransferase	-
CTT34_RS04780	981667..982137	+	471	WP_159341423.1	GNAT family N-acetyltransferase	-
CTT34_RS04785	982181..982609	+	429	WP_159341424.1	GFA family protein	-
CTT34_RS04790	982667..983548	+	882	WP_159341425.1	class A beta-lactamase	-
CTT34_RS04795	983659..984219	-	561	WP_159341426.1	manganese efflux pump MntP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10234.85 Da
• Isoelectric Point: 9.8162

>T88100 WP_016914643.1 NZ_CP024621:c979115-978861 [Halomonas meridiana]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKEIKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLVAQL
RYHY

Nucleotide

• Length: 255 bp

>T88100 NZ_CP024621:c979115-978861 [Halomonas meridiana]
ATGAAGCTCATCTTTTCCGAGAACGCCTGGGAAGACTATTTGTACTGGCAGAAAACTGACAAAAAGATTCTCAACCGAAT
CAACAAGCTAATCAAAGAAATCAAGCGAGAGCCATTTGAAGGAGTCGGCAAGCCAGAACCCCTTAAACACAGCCTCGCGG
GTTACTGGTCTCGGCGAATCAACGAAGAACACCGCATCGTTTACAAGGTCACGGACGACGCTTTGCTTGTTGCCCAGCTG
CGGTATCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9298.56 Da
• Isoelectric Point: 4.4750

>AT88100 WP_159341419.1 NZ_CP024621:c979363-979112 [Halomonas meridiana]
MDAISYTAARTNLAKTMEQVCEDHSPMIITRNKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVGELEQGGGQEKE
LLE

Nucleotide

• Length: 252 bp

>AT88100 NZ_CP024621:c979363-979112 [Halomonas meridiana]
ATGGATGCCATCAGCTACACCGCCGCTAGAACCAATCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCACTCTCCTAT
GATCATCACCCGCAATAAGGCGCAATCCGTGGTCATGATCTCTCTCGAAGACTACGAAGCACTGCAAGAGACAGCCTATC
TCCTGCGCGCGCCCAAGAACGCCCGCCGTTTACTGGAATCCGTTGGCGAGCTGGAGCAAGGGGGCGGTCAGGAAAAGGAG
CTTCTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A857GIF8