Detailed information of TA system TA088099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 843809..844926
• Replicon: chromosome
• Accession: NZ_CP024621
• Organism: Halomonas meridiana strain SCSIO 43005

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CTT34_RS04145
• Protein ID: WP_159341305.1
• Coordinates: 844177..844926 (+)
• Length: 250 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CTT34_RS04140
• Protein ID: WP_159341304.1
• Coordinates: 843809..844180 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTT34_RS04120	839165..840238	+	1074	WP_159341300.1	DUF4401 domain-containing protein	-
CTT34_RS04125	840228..840749	+	522	WP_159341301.1	GDYXXLXY domain-containing protein	-
CTT34_RS04130	840848..841795	+	948	WP_159341302.1	pirin family protein	-
CTT34_RS04135	841937..843733	+	1797	WP_159341303.1	mechanosensitive ion channel	-
CTT34_RS04140	843809..844180	+	372	WP_159341304.1	DUF2384 domain-containing protein	Antitoxin
CTT34_RS04145	844177..844926	+	750	WP_159341305.1	RES family NAD+ phosphorylase	Toxin
CTT34_RS04150	844962..845300	-	339	WP_159341306.1	DUF952 domain-containing protein	-
CTT34_RS04155	845348..848818	-	3471	WP_159341307.1	acyl-[ACP]--phospholipid O-acyltransferase	-
CTT34_RS04160	848953..849723	+	771	WP_159341308.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-205)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (70-121)

Sequences

Toxin

Protein

• Length: 250 a.a.
• Molecular weight: 27750.32 Da
• Isoelectric Point: 5.6194

>T88099 WP_159341305.1 NZ_CP024621:844177-844926 [Halomonas meridiana]
VSIWERCDGTSHIVPISGTLYRLVESQEQVATLSYVDTLEEQEILEALLETAKPPYPKQERDLHYLLKTPFRYPPLKWGS
RFGRVHEPSIFYGGQTIPTTLAESAYYRWVFWYSMEGTPAADSLRSEHTLFSVGYAVTKGVTLNSEVFAKHQAVLRHPVE
YAPCQQVGSAMRAAGVEAFEYASARDPAGGSCVGLFTPSALTQQQPADMQSWFCVTTADQVSFKRKDAAGVTTFELSEFL
YRGGLPFPA

Nucleotide

• Length: 750 bp

>T88099 NZ_CP024621:844177-844926 [Halomonas meridiana]
GTGAGCATTTGGGAACGCTGTGATGGCACAAGCCATATCGTGCCTATTTCCGGCACGCTGTATCGGTTGGTTGAGAGCCA
GGAGCAAGTCGCGACCCTAAGCTACGTCGATACGTTAGAAGAGCAGGAAATATTGGAAGCACTGCTCGAAACGGCCAAGC
CTCCCTATCCTAAGCAGGAGCGCGACCTTCACTACCTGTTAAAAACGCCTTTTCGATATCCGCCCCTCAAATGGGGGTCT
CGGTTTGGCCGTGTCCATGAGCCTAGCATCTTCTACGGTGGGCAAACGATACCGACGACTCTCGCTGAGTCTGCCTACTA
TCGTTGGGTGTTTTGGTACTCAATGGAAGGCACGCCAGCGGCGGACTCTCTACGTTCAGAGCACACGCTATTTTCGGTGG
GCTACGCCGTTACGAAGGGAGTAACACTGAACTCAGAAGTTTTTGCCAAGCATCAAGCAGTGTTAAGGCATCCCGTGGAG
TATGCCCCTTGCCAACAAGTAGGCAGCGCCATGCGAGCCGCAGGAGTAGAAGCGTTCGAATATGCGTCAGCTAGAGACCC
TGCGGGCGGCAGCTGTGTAGGTTTGTTCACACCCAGCGCGCTCACCCAACAGCAGCCTGCCGATATGCAGTCGTGGTTTT
GTGTTACGACTGCCGATCAAGTCTCCTTCAAGCGCAAAGATGCTGCTGGGGTAACGACCTTTGAACTGAGTGAGTTTCTC
TATCGCGGCGGTTTGCCGTTTCCGGCGTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13339.62 Da
• Isoelectric Point: 11.5232

>AT88099 WP_159341304.1 NZ_CP024621:843809-844180 [Halomonas meridiana]
MPALAQSRSTPDQVLAKAVLRAAEQLGLSQSALADVLGVHRTTITQLKKNLKLDPNSKQGELALLLIRLARALFALTGGD
QVWIQHFMRTPNRATGGVPAEQVTRLEGLFAVLRFVDGMRGKV

Nucleotide

• Length: 372 bp

>AT88099 NZ_CP024621:843809-844180 [Halomonas meridiana]
ATGCCTGCGCTTGCTCAATCTAGGTCGACGCCTGATCAGGTACTCGCGAAAGCGGTGCTACGTGCTGCTGAGCAATTGGG
GTTATCGCAATCAGCGTTAGCTGACGTGCTAGGGGTACACCGCACCACCATTACGCAGCTAAAGAAAAATTTGAAGCTTG
ACCCAAACTCTAAACAAGGCGAGCTGGCGCTACTGCTGATTCGTTTAGCGCGAGCGCTGTTCGCCTTGACGGGAGGAGAT
CAAGTATGGATTCAGCACTTTATGCGCACGCCCAACCGTGCCACGGGGGGCGTGCCTGCTGAACAAGTCACACGGCTAGA
GGGGCTGTTCGCAGTCCTTAGATTCGTTGATGGGATGCGGGGCAAGGTGTGA