Detailed information of TA system TA088098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2368596..2369218
• Replicon: chromosome
• Accession: NZ_CP024620
• Organism: Acinetobacter indicus strain SGAir0564

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CTZ23_RS11480
• Protein ID: WP_104989019.1
• Coordinates: 2368823..2369218 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: N8WVG5
• Locus tag: CTZ23_RS11475
• Protein ID: WP_004779823.1
• Coordinates: 2368596..2368826 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTZ23_RS11435	2364692..2365012	+	321	WP_002126330.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CTZ23_RS11440	2365005..2365277	+	273	WP_002126333.1	helix-turn-helix domain-containing protein	-
CTZ23_RS11445	2365361..2366002	-	642	WP_104989018.1	hypothetical protein	-
CTZ23_RS11450	2366082..2366390	+	309	Protein_2224	type VI secretion system tip protein VgrG	-
CTZ23_RS11460	2367206..2367502	+	297	WP_104989400.1	hypothetical protein	-
CTZ23_RS11465	2367517..2368029	+	513	WP_104989401.1	hypothetical protein	-
CTZ23_RS11475	2368596..2368826	+	231	WP_004779823.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CTZ23_RS11480	2368823..2369218	+	396	WP_104989019.1	type II toxin-antitoxin system VapC family toxin	Toxin
CTZ23_RS11485	2369252..2370460	-	1209	WP_104987963.1	IS256 family transposase	-
CTZ23_RS11490	2370779..2371177	-	399	WP_104989020.1	hypothetical protein	-
CTZ23_RS11495	2371399..2372343	+	945	WP_201798500.1	tRNA-dihydrouridine synthase	-
CTZ23_RS11500	2372426..2372830	-	405	WP_104989402.1	NUDIX domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	bfmS / bfmR / pilT / pilU / tufA	2275185..2507411	232226
	-	flank	IS/Tn	-	-	2369252..2370460	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-37)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14893.12 Da
• Isoelectric Point: 6.2253

>T88098 WP_104989019.1 NZ_CP024620:2368823-2369218 [Acinetobacter indicus]
MIYLLDTNICIYVINNKPQHVFERFRQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQDLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWG

Nucleotide

• Length: 396 bp

>T88098 NZ_CP024620:2368823-2369218 [Acinetobacter indicus]
ATGATTTACCTCTTAGACACAAATATTTGTATCTATGTCATCAATAATAAGCCTCAACACGTTTTTGAGCGCTTTAGGCA
ATATCAACTCGGCCAGCTTGCGATTTCGAGTATCACGGCATCTGAGCTGGCTTTCGGTGTAGAGAAGTCTGGATCTGAAC
GCAATAAACAGGCGTTAAACAAGTTTTTGTCACCTTTAGAGATTCTTCCTTACGATGAACAAGCAATTTGGCATTACGCC
AAATTACGCCAAGATCTTCAATCCACAGGTAAACCGATTGGCAGCTTAGATATGCTGATCGCTGCTCATGCTTTGGCATT
GGATGTTGTATTAGTAACGAACAATACAAAAGAATTTGAACGGATTGATGGTCTGAAGCTAGAGAATTGGGGCTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8750.97 Da
• Isoelectric Point: 4.7708

>AT88098 WP_004779823.1 NZ_CP024620:2368596-2368826 [Acinetobacter indicus]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEGGFQLERADQGEQFREEFR

Nucleotide

• Length: 231 bp

>AT88098 NZ_CP024620:2368596-2368826 [Acinetobacter indicus]
ATGGAAATTGCGAAAGTATTCCAAACTGGTCGCAGTCAGGCTGTTCGCTTGCCTAAAGCCTTTCGCTTTAATGGCACGGA
AGTGGCCATCAAAAGTTTCGGGCGTGGTGTATTACTCATGCCCATCGACAATCCTTGGGATGTCATGTTAGAAGCCATCA
ATGAGTTTGAGGGTGGATTCCAATTGGAGCGAGCTGATCAAGGCGAACAGTTCCGTGAGGAGTTCAGATGA

Structures

Antitoxin

• AlphaFold DB: N8WVG5