Detailed information of TA system TA088094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 239755..240283
• Replicon: chromosome
• Accession: NZ_CP024620
• Organism: Acinetobacter indicus strain SGAir0564

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: CTZ23_RS01155
• Protein ID: WP_000221358.1
• Coordinates: 239990..240283 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CTZ23_RS01150
• Protein ID: WP_104988060.1
• Coordinates: 239755..240000 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTZ23_RS01125	235318..235569	+	252	WP_104988057.1	DUF4041 domain-containing protein	-
CTZ23_RS01135	236454..238319	+	1866	WP_104988058.1	copper resistance system multicopper oxidase	-
CTZ23_RS01140	238306..238644	+	339	WP_104988059.1	hypothetical protein	-
CTZ23_RS01145	238631..239575	+	945	WP_004668309.1	copper resistance protein B	-
CTZ23_RS01150	239755..240000	+	246	WP_104988060.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CTZ23_RS01155	239990..240283	+	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CTZ23_RS01160	240322..241473	-	1152	WP_005176703.1	IS4 family transposase	-
CTZ23_RS01165	241691..242020	-	330	WP_004641881.1	four-helix bundle copper-binding protein	-
CTZ23_RS01175	242284..243216	-	933	WP_104988061.1	IS5 family transposase	-
CTZ23_RS01180	243270..243785	+	516	Protein_226	IS3 family transposase	-
CTZ23_RS01185	244492..245055	+	564	WP_005180661.1	alkyl hydroperoxide reductase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	177499..243785	66286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T88094 WP_000221358.1 NZ_CP024620:239990-240283 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T88094 NZ_CP024620:239990-240283 [Acinetobacter indicus]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9279.66 Da
• Isoelectric Point: 4.3142

>AT88094 WP_104988060.1 NZ_CP024620:239755-240000 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT88094 NZ_CP024620:239755-240000 [Acinetobacter indicus]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTACACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4