Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2325584..2326222 Replicon chromosome
Accession NZ_CP024618
Organism Escherichia coli strain SMN152SH1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CR916_RS13700 Protein ID WP_032195248.1
Coordinates 2326046..2326222 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CR916_RS13695 Protein ID WP_077879189.1
Coordinates 2325584..2326000 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR916_RS13675 2320738..2321679 - 942 WP_001251313.1 ABC transporter permease -
CR916_RS13680 2321680..2322657 - 978 WP_095585825.1 ABC transporter ATP-binding protein -
CR916_RS13685 2322709..2323854 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
CR916_RS13690 2324099..2325505 - 1407 WP_000760615.1 PLP-dependent aminotransferase family protein -
CR916_RS13695 2325584..2326000 - 417 WP_077879189.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
CR916_RS13700 2326046..2326222 - 177 WP_032195248.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
CR916_RS13705 2326444..2326674 + 231 WP_000494244.1 YncJ family protein -
CR916_RS13710 2326766..2328727 - 1962 WP_024177737.1 23S rRNA 5-hydroxycytidine C2501 synthase -
CR916_RS13715 2328800..2329336 - 537 WP_062881684.1 DNA-binding transcriptional regulator SutR -
CR916_RS13720 2329389..2330603 + 1215 WP_071796541.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espM1 / nleF 2325584..2424674 99090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6709.81 Da        Isoelectric Point: 11.2298

>T88078 WP_032195248.1 NZ_CP024618:c2326222-2326046 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRPPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T88078 NZ_CP024618:c2326222-2326046 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCCCCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15232.60 Da        Isoelectric Point: 4.7386

>AT88078 WP_077879189.1 NZ_CP024618:c2326000-2325584 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPVSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT88078 NZ_CP024618:c2326000-2325584 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTGTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References