Detailed information of TA system TA088072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1566638..1567116
• Replicon: chromosome
• Accession: NZ_CP024618
• Organism: Escherichia coli strain SMN152SH1

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: CR916_RS09320
• Protein ID: WP_001303876.1
• Coordinates: 1566638..1566925 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: CR916_RS09325
• Protein ID: WP_000536233.1
• Coordinates: 1566925..1567116 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CR916_RS09280	1561824..1564259	-	2436	WP_101975670.1	exonuclease	-
CR916_RS09285	1564353..1564544	-	192	WP_001098307.1	DUF1482 family protein	-
CR916_RS09290	1564541..1564729	-	189	WP_000413705.1	cell division inhibition protein DicB	-
CR916_RS09300	1565303..1565488	+	186	WP_032205087.1	hypothetical protein	-
CR916_RS09305	1565675..1566064	-	390	WP_032205089.1	hypothetical protein	-
CR916_RS09315	1566206..1566361	-	156	WP_000379575.1	DUF1391 family protein	-
CR916_RS09320	1566638..1566925	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CR916_RS09325	1566925..1567116	-	192	WP_000536233.1	hypothetical protein	Antitoxin
CR916_RS09330	1567144..1567545	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
CR916_RS09335	1567654..1567926	+	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
CR916_RS09340	1567910..1568005	+	96	Protein_1535	Rha family transcriptional regulator	-
CR916_RS30685	1567992..1568417	-	426	WP_176465538.1	hypothetical protein	-
CR916_RS09350	1568552..1568749	-	198	WP_000917737.1	hypothetical protein	-
CR916_RS09355	1569036..1569854	-	819	WP_000265267.1	CPBP family intramembrane metalloprotease	-
CR916_RS09360	1570006..1570377	-	372	WP_000090265.1	antitermination protein	-
CR916_RS09365	1570367..1570738	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
CR916_RS09370	1570751..1571800	-	1050	WP_001265133.1	DUF968 domain-containing protein	-
CR916_RS09375	1571802..1572080	-	279	WP_074433979.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T88072 WP_001303876.1 NZ_CP024618:c1566925-1566638 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T88072 NZ_CP024618:c1566925-1566638 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT88072 WP_000536233.1 NZ_CP024618:c1567116-1566925 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT88072 NZ_CP024618:c1567116-1566925 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA