Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 937789..938407 Replicon chromosome
Accession NZ_CP024618
Organism Escherichia coli strain SMN152SH1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CR916_RS05970 Protein ID WP_001291435.1
Coordinates 937789..938007 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CR916_RS05975 Protein ID WP_000344800.1
Coordinates 938033..938407 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR916_RS05935 933077..933649 + 573 WP_000779826.1 lipoprotein -
CR916_RS05940 933680..933991 - 312 WP_000409911.1 MGMT family protein -
CR916_RS05950 934370..934723 + 354 WP_000878140.1 DUF1428 domain-containing protein -
CR916_RS05955 934765..936315 - 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CR916_RS05960 936480..936950 - 471 WP_062882209.1 YlaC family protein -
CR916_RS05965 937066..937617 - 552 WP_000102569.1 maltose O-acetyltransferase -
CR916_RS05970 937789..938007 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CR916_RS05975 938033..938407 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CR916_RS05980 938953..942102 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
CR916_RS05985 942125..943318 - 1194 WP_062882208.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T88070 WP_001291435.1 NZ_CP024618:c938007-937789 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T88070 NZ_CP024618:c938007-937789 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT88070 WP_000344800.1 NZ_CP024618:c938407-938033 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT88070 NZ_CP024618:c938407-938033 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References