Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1047720..1048371 Replicon chromosome
Accession NZ_CP024613
Organism Acinetobacter baumannii strain Ab4568

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag CTZ19_RS05130 Protein ID WP_000838146.1
Coordinates 1047720..1047902 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag CTZ19_RS05135 Protein ID WP_000966689.1
Coordinates 1047967..1048371 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTZ19_RS05085 1042977..1043642 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
CTZ19_RS05090 1043647..1044036 + 390 WP_000008492.1 hypothetical protein -
CTZ19_RS05095 1044038..1044406 + 369 WP_000524231.1 hypothetical protein -
CTZ19_RS05100 1044415..1044819 + 405 WP_000248324.1 hypothetical protein -
CTZ19_RS05105 1044791..1045159 + 369 WP_000539752.1 hypothetical protein -
CTZ19_RS05110 1045161..1045559 + 399 WP_001132270.1 hypothetical protein -
CTZ19_RS05115 1045561..1045773 + 213 WP_000121166.1 hypothetical protein -
CTZ19_RS05120 1045881..1046810 + 930 WP_000094300.1 hypothetical protein -
CTZ19_RS05125 1046855..1047388 + 534 WP_001185622.1 hypothetical protein -
CTZ19_RS05130 1047720..1047902 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
CTZ19_RS05135 1047967..1048371 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CTZ19_RS05140 1048452..1048853 + 402 WP_000720591.1 hypothetical protein -
CTZ19_RS05145 1048914..1052879 + 3966 WP_000191304.1 tape measure protein -
CTZ19_RS05150 1052997..1053338 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1017327..1071942 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T88057 WP_000838146.1 NZ_CP024613:1047720-1047902 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T88057 NZ_CP024613:1047720-1047902 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT88057 WP_000966689.1 NZ_CP024613:1047967-1048371 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT88057 NZ_CP024613:1047967-1048371 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References