Detailed information of TA system TA088055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1586571..1587250
• Replicon: chromosome
• Accession: NZ_CP024612
• Organism: Acinetobacter baumannii strain Ab4653

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: CTZ18_RS07645
• Protein ID: WP_000838146.1
• Coordinates: 1586571..1586753 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: CTZ18_RS07650
• Protein ID: WP_000966688.1
• Coordinates: 1586846..1587250 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTZ18_RS19100	1581745..1581915	+	171	WP_169051393.1	hypothetical protein	-
CTZ18_RS07600	1581927..1582331	+	405	WP_033918538.1	hypothetical protein	-
CTZ18_RS07605	1582303..1582671	+	369	WP_033918539.1	hypothetical protein	-
CTZ18_RS07610	1582628..1583071	+	444	WP_079378908.1	hypothetical protein	-
CTZ18_RS07615	1583073..1583291	+	219	WP_001277694.1	hypothetical protein	-
CTZ18_RS07620	1583350..1583703	+	354	WP_033918541.1	hypothetical protein	-
CTZ18_RS07625	1583703..1584689	+	987	WP_099973753.1	phage tail protein	-
CTZ18_RS07630	1584742..1585659	+	918	WP_000094250.1	hypothetical protein	-
CTZ18_RS07635	1585730..1586245	+	516	WP_024616020.1	hypothetical protein	-
CTZ18_RS07645	1586571..1586753	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
CTZ18_RS07650	1586846..1587250	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CTZ18_RS07655	1587349..1587873	+	525	WP_099973754.1	DUF4468 domain-containing protein	-
CTZ18_RS07660	1587937..1588860	+	924	WP_000732599.1	hypothetical protein	-
CTZ18_RS07665	1588877..1589143	-	267	WP_000774878.1	hypothetical protein	-
CTZ18_RS07670	1589293..1590237	+	945	WP_099973755.1	ORF6N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1555061..1607582	52521

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T88055 WP_000838146.1 NZ_CP024612:1586571-1586753 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T88055 NZ_CP024612:1586571-1586753 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT88055 WP_000966688.1 NZ_CP024612:1586846-1587250 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT88055 NZ_CP024612:1586846-1587250 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6