Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1013157..1013808 Replicon chromosome
Accession NZ_CP024611
Organism Acinetobacter baumannii strain Ab4977

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag CTZ20_RS04890 Protein ID WP_000838146.1
Coordinates 1013157..1013339 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag CTZ20_RS04895 Protein ID WP_000966689.1
Coordinates 1013404..1013808 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTZ20_RS04845 1008414..1009079 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
CTZ20_RS04850 1009084..1009473 + 390 WP_000008492.1 hypothetical protein -
CTZ20_RS04855 1009475..1009843 + 369 WP_000524231.1 hypothetical protein -
CTZ20_RS04860 1009852..1010256 + 405 WP_000248324.1 hypothetical protein -
CTZ20_RS04865 1010228..1010596 + 369 WP_000539752.1 hypothetical protein -
CTZ20_RS04870 1010598..1010996 + 399 WP_001132270.1 hypothetical protein -
CTZ20_RS04875 1010998..1011210 + 213 WP_000121166.1 hypothetical protein -
CTZ20_RS04880 1011318..1012247 + 930 WP_000094300.1 hypothetical protein -
CTZ20_RS04885 1012292..1012825 + 534 WP_001185622.1 hypothetical protein -
CTZ20_RS04890 1013157..1013339 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
CTZ20_RS04895 1013404..1013808 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CTZ20_RS04900 1013889..1014290 + 402 WP_000720591.1 hypothetical protein -
CTZ20_RS04905 1014351..1018316 + 3966 WP_000191304.1 tape measure protein -
CTZ20_RS04910 1018434..1018775 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 978783..1037379 58596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T88053 WP_000838146.1 NZ_CP024611:1013157-1013339 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T88053 NZ_CP024611:1013157-1013339 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT88053 WP_000966689.1 NZ_CP024611:1013404-1013808 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT88053 NZ_CP024611:1013404-1013808 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References