Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1339774..1341012 Replicon chromosome
Accession NZ_CP024590
Organism Enterococcus avium strain FDAARGOS_184

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag AUF16_RS06665 Protein ID WP_148712552.1
Coordinates 1339774..1340742 (-) Length 323 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID -
Locus tag AUF16_RS06670 Protein ID WP_192575117.1
Coordinates 1340743..1341012 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUF16_RS06635 1335961..1336254 - 294 WP_148712548.1 hypothetical protein -
AUF16_RS18610 1336603..1336812 + 210 WP_192575115.1 hypothetical protein -
AUF16_RS06650 1337865..1338137 + 273 WP_192575130.1 hypothetical protein -
AUF16_RS18615 1338201..1338338 + 138 WP_192575116.1 hypothetical protein -
AUF16_RS06655 1338766..1339344 - 579 WP_148712550.1 recombinase family protein -
AUF16_RS06660 1339359..1339661 - 303 WP_148712551.1 BRCT domain-containing protein -
AUF16_RS06665 1339774..1340742 - 969 WP_148712552.1 zeta toxin family protein Toxin
AUF16_RS06670 1340743..1341012 - 270 WP_192575117.1 antitoxin Antitoxin
AUF16_RS06675 1341031..1341297 - 267 WP_123864213.1 helix-turn-helix domain-containing protein -
AUF16_RS06680 1341284..1341643 - 360 WP_148712554.1 type II toxin-antitoxin system RelE/ParE family toxin -
AUF16_RS06685 1341716..1343215 - 1500 WP_148712555.1 relaxase/mobilization nuclease domain-containing protein -
AUF16_RS06690 1343218..1343586 - 369 WP_148712556.1 plasmid mobilization relaxosome protein MobC -
AUF16_RS06695 1344203..1344478 - 276 WP_148712557.1 hypothetical protein -
AUF16_RS06700 1344475..1345512 - 1038 WP_148712558.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - esp / prgB/asc10 1163492..1362949 199457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(29-215)

Antitoxin

Bacterial epsilon antitoxin

(3-88)


Sequences

Toxin        


Download         Length: 323 a.a.        Molecular weight: 37332.79 Da        Isoelectric Point: 6.0809

>T88046 WP_148712552.1 NZ_CP024590:c1340742-1339774 [Enterococcus avium]
MMDDLFAYSEEQYCAIFEDLIEDLTYSMNPTKNPQAFILGGQSGAGKSTLHKLILEEMQGNIIIIDNDTFKPLHPNYDQL
AEKIGVEVTEYVKPFSNRLTNGLIDYLSDQKYNLIIEGTLRTTETPIKTNTQLKNKGYSTNLYVIATQSELSYLSTLERY
LDMYLDEPETARATPKVIHDEIVKAIPGNLETLYNHHIFNEIKVLTRQGELLYSMQSTPLKSPRSVLEEKLTCVLNMDQR
ENIYGRLEQKLQRIKENAVIENKILMEIETRVVSYKNLQRDMTKPNQTILQKEIEQARKEQEKLLKNRLSSMNKEKTKPK
RL

Download         Length: 969 bp

>T88046 NZ_CP024590:c1340742-1339774 [Enterococcus avium]
ATGATGGACGACTTATTCGCTTACTCAGAGGAGCAGTATTGTGCGATTTTCGAGGATTTAATTGAAGACTTAACTTATTC
GATGAATCCGACTAAAAACCCGCAAGCTTTTATTCTAGGTGGGCAATCAGGTGCAGGAAAATCAACACTTCACAAATTGA
TATTGGAAGAGATGCAAGGGAATATTATTATTATTGATAATGATACATTTAAACCTTTACATCCGAATTATGATCAATTA
GCTGAAAAAATTGGCGTTGAAGTAACAGAATACGTCAAACCATTTTCCAATCGCCTCACAAATGGACTAATCGATTACCT
AAGTGATCAAAAGTATAACCTAATTATAGAAGGAACATTGAGAACGACTGAAACACCAATAAAAACAAACACTCAATTAA
AAAATAAGGGCTATTCCACAAATCTATATGTGATTGCTACTCAAAGTGAATTGTCTTATTTGAGCACTTTAGAAAGATAC
CTGGATATGTATTTAGATGAACCAGAGACTGCGCGAGCAACACCTAAAGTGATTCATGATGAAATTGTTAAAGCCATTCC
AGGGAATTTAGAAACGCTTTATAATCACCATATTTTTAACGAGATAAAAGTTTTAACTAGACAGGGGGAACTTTTATATT
CCATGCAATCAACCCCTTTAAAATCGCCCAGATCAGTATTAGAAGAAAAACTAACTTGCGTTTTGAATATGGATCAACGA
GAAAACATATATGGTAGATTAGAACAGAAGTTACAGCGAATCAAAGAAAATGCTGTCATAGAAAATAAGATACTGATGGA
AATTGAAACGAGAGTCGTATCATATAAAAACTTACAAAGAGATATGACTAAGCCTAATCAAACGATTTTACAAAAAGAAA
TTGAACAAGCCAGAAAGGAACAGGAAAAACTACTAAAAAATAGATTGTCATCAATGAATAAAGAAAAAACGAAACCAAAA
CGGTTATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10612.26 Da        Isoelectric Point: 8.0053

>AT88046 WP_192575117.1 NZ_CP024590:c1341012-1340743 [Enterococcus avium]
VKVNYDEVYQVELIKELSARVYGRLLNMILEAGYDKTDTSIFECLLLQQFKEHKRSNLFDKNLKELEELKAYWHSMNQLT
KDLSKKRVA

Download         Length: 270 bp

>AT88046 NZ_CP024590:c1341012-1340743 [Enterococcus avium]
GTGAAAGTGAACTATGATGAAGTATATCAAGTGGAGTTAATTAAAGAGTTGTCCGCAAGAGTATATGGTCGATTACTAAA
CATGATTTTAGAAGCAGGATATGATAAAACGGATACGTCTATTTTTGAGTGCTTACTTTTACAACAATTTAAAGAGCACA
AAAGGAGTAATTTATTCGATAAAAACTTGAAAGAATTGGAAGAGCTCAAAGCATATTGGCATTCGATGAATCAGCTTACA
AAAGATCTATCCAAGAAACGAGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References