Detailed information of TA system TA088046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1339774..1341012
• Replicon: chromosome
• Accession: NZ_CP024590
• Organism: Enterococcus avium strain FDAARGOS_184

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: AUF16_RS06665
• Protein ID: WP_148712552.1
• Coordinates: 1339774..1340742 (-)
• Length: 323 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: -
• Locus tag: AUF16_RS06670
• Protein ID: WP_192575117.1
• Coordinates: 1340743..1341012 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUF16_RS06635	1335961..1336254	-	294	WP_148712548.1	hypothetical protein	-
AUF16_RS18610	1336603..1336812	+	210	WP_192575115.1	hypothetical protein	-
AUF16_RS06650	1337865..1338137	+	273	WP_192575130.1	hypothetical protein	-
AUF16_RS18615	1338201..1338338	+	138	WP_192575116.1	hypothetical protein	-
AUF16_RS06655	1338766..1339344	-	579	WP_148712550.1	recombinase family protein	-
AUF16_RS06660	1339359..1339661	-	303	WP_148712551.1	BRCT domain-containing protein	-
AUF16_RS06665	1339774..1340742	-	969	WP_148712552.1	zeta toxin family protein	Toxin
AUF16_RS06670	1340743..1341012	-	270	WP_192575117.1	antitoxin	Antitoxin
AUF16_RS06675	1341031..1341297	-	267	WP_123864213.1	helix-turn-helix domain-containing protein	-
AUF16_RS06680	1341284..1341643	-	360	WP_148712554.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AUF16_RS06685	1341716..1343215	-	1500	WP_148712555.1	relaxase/mobilization nuclease domain-containing protein	-
AUF16_RS06690	1343218..1343586	-	369	WP_148712556.1	plasmid mobilization relaxosome protein MobC	-
AUF16_RS06695	1344203..1344478	-	276	WP_148712557.1	hypothetical protein	-
AUF16_RS06700	1344475..1345512	-	1038	WP_148712558.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	esp / prgB/asc10	1163492..1362949	199457

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (29-215)

Antitoxin

• Bacterial epsilon antitoxin (3-88)

Sequences

Toxin

Protein

• Length: 323 a.a.
• Molecular weight: 37332.79 Da
• Isoelectric Point: 6.0809

>T88046 WP_148712552.1 NZ_CP024590:c1340742-1339774 [Enterococcus avium]
MMDDLFAYSEEQYCAIFEDLIEDLTYSMNPTKNPQAFILGGQSGAGKSTLHKLILEEMQGNIIIIDNDTFKPLHPNYDQL
AEKIGVEVTEYVKPFSNRLTNGLIDYLSDQKYNLIIEGTLRTTETPIKTNTQLKNKGYSTNLYVIATQSELSYLSTLERY
LDMYLDEPETARATPKVIHDEIVKAIPGNLETLYNHHIFNEIKVLTRQGELLYSMQSTPLKSPRSVLEEKLTCVLNMDQR
ENIYGRLEQKLQRIKENAVIENKILMEIETRVVSYKNLQRDMTKPNQTILQKEIEQARKEQEKLLKNRLSSMNKEKTKPK
RL

Nucleotide

• Length: 969 bp

>T88046 NZ_CP024590:c1340742-1339774 [Enterococcus avium]
ATGATGGACGACTTATTCGCTTACTCAGAGGAGCAGTATTGTGCGATTTTCGAGGATTTAATTGAAGACTTAACTTATTC
GATGAATCCGACTAAAAACCCGCAAGCTTTTATTCTAGGTGGGCAATCAGGTGCAGGAAAATCAACACTTCACAAATTGA
TATTGGAAGAGATGCAAGGGAATATTATTATTATTGATAATGATACATTTAAACCTTTACATCCGAATTATGATCAATTA
GCTGAAAAAATTGGCGTTGAAGTAACAGAATACGTCAAACCATTTTCCAATCGCCTCACAAATGGACTAATCGATTACCT
AAGTGATCAAAAGTATAACCTAATTATAGAAGGAACATTGAGAACGACTGAAACACCAATAAAAACAAACACTCAATTAA
AAAATAAGGGCTATTCCACAAATCTATATGTGATTGCTACTCAAAGTGAATTGTCTTATTTGAGCACTTTAGAAAGATAC
CTGGATATGTATTTAGATGAACCAGAGACTGCGCGAGCAACACCTAAAGTGATTCATGATGAAATTGTTAAAGCCATTCC
AGGGAATTTAGAAACGCTTTATAATCACCATATTTTTAACGAGATAAAAGTTTTAACTAGACAGGGGGAACTTTTATATT
CCATGCAATCAACCCCTTTAAAATCGCCCAGATCAGTATTAGAAGAAAAACTAACTTGCGTTTTGAATATGGATCAACGA
GAAAACATATATGGTAGATTAGAACAGAAGTTACAGCGAATCAAAGAAAATGCTGTCATAGAAAATAAGATACTGATGGA
AATTGAAACGAGAGTCGTATCATATAAAAACTTACAAAGAGATATGACTAAGCCTAATCAAACGATTTTACAAAAAGAAA
TTGAACAAGCCAGAAAGGAACAGGAAAAACTACTAAAAAATAGATTGTCATCAATGAATAAAGAAAAAACGAAACCAAAA
CGGTTATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10612.26 Da
• Isoelectric Point: 8.0053

>AT88046 WP_192575117.1 NZ_CP024590:c1341012-1340743 [Enterococcus avium]
VKVNYDEVYQVELIKELSARVYGRLLNMILEAGYDKTDTSIFECLLLQQFKEHKRSNLFDKNLKELEELKAYWHSMNQLT
KDLSKKRVA

Nucleotide

• Length: 270 bp

>AT88046 NZ_CP024590:c1341012-1340743 [Enterococcus avium]
GTGAAAGTGAACTATGATGAAGTATATCAAGTGGAGTTAATTAAAGAGTTGTCCGCAAGAGTATATGGTCGATTACTAAA
CATGATTTTAGAAGCAGGATATGATAAAACGGATACGTCTATTTTTGAGTGCTTACTTTTACAACAATTTAAAGAGCACA
AAAGGAGTAATTTATTCGATAAAAACTTGAAAGAATTGGAAGAGCTCAAAGCATATTGGCATTCGATGAATCAGCTTACA
AAAGATCTATCCAAGAAACGAGTGGCATAA