Detailed information of TA system TA088044

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1238662..1239173
• Replicon: chromosome
• Accession: NZ_CP024590
• Organism: Enterococcus avium strain FDAARGOS_184

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AUF16_RS06095
• Protein ID: WP_148712487.1
• Coordinates: 1238662..1238946 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R3JPM7
• Locus tag: AUF16_RS06100
• Protein ID: WP_002413218.1
• Coordinates: 1238946..1239173 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUF16_RS06070	1233985..1234902	+	918	WP_148712484.1	hypothetical protein	-
AUF16_RS06075	1234940..1235536	-	597	WP_148712485.1	sce7726 family protein	-
AUF16_RS06090	1236942..1238505	-	1564	Protein_1176	IS1182 family transposase	-
AUF16_RS06095	1238662..1238946	-	285	WP_148712487.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AUF16_RS06100	1238946..1239173	-	228	WP_002413218.1	antitoxin	Antitoxin
AUF16_RS06105	1239233..1239724	-	492	Protein_1179	hypothetical protein	-
AUF16_RS18580	1240237..1240623	-	387	WP_192575134.1	hypothetical protein	-
AUF16_RS18585	1240841..1241014	-	174	WP_192575111.1	hypothetical protein	-
AUF16_RS06115	1241519..1241956	-	438	WP_148712488.1	hypothetical protein	-
AUF16_RS06120	1241956..1242255	-	300	WP_148712489.1	helix-turn-helix domain-containing protein	-
AUF16_RS06125	1242330..1242530	+	201	WP_148712490.1	hypothetical protein	-
AUF16_RS06130	1242502..1242690	-	189	WP_148712491.1	hypothetical protein	-
AUF16_RS18590	1242910..1243122	-	213	WP_192575112.1	hypothetical protein	-
AUF16_RS06140	1243246..1243995	+	750	WP_148712492.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	esp / prgB/asc10	1163492..1362949	199457

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11179.86 Da
• Isoelectric Point: 10.3904

>T88044 WP_148712487.1 NZ_CP024590:c1238946-1238662 [Enterococcus avium]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTVNPREQGKSLSANCAGQWRYRIGNYRIIVEIEDERLVVTAIQV
GHRRNIYDRSKMGQ

Nucleotide

• Length: 285 bp

>T88044 NZ_CP024590:c1238946-1238662 [Enterococcus avium]
ATGTCGTACCGATTAGAATTTACTCCTGATGTAAAAAAACAGTTAAAAAAAATGGATAAATATCAAGCGACATTGTTAAC
AAGATGGTTGTATCGAAATATTGATGGAACGGTCAATCCTAGAGAGCAAGGAAAATCTTTATCAGCAAATTGTGCAGGTC
AGTGGCGATATAGAATAGGGAATTATCGTATCATTGTAGAAATAGAAGATGAGCGTCTAGTAGTAACAGCAATTCAGGTA
GGACATAGAAGAAATATTTATGATAGGTCGAAAATGGGGCAATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8785.90 Da
• Isoelectric Point: 4.0179

>AT88044 WP_002413218.1 NZ_CP024590:c1239173-1238946 [Enterococcus avium]
MAMITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Nucleotide

• Length: 228 bp

>AT88044 NZ_CP024590:c1239173-1238946 [Enterococcus avium]
ATGGCTATGATTACTGTAAGAGTAAGTGATGAAGAAAAAGAATGGCTTTCTTACATGGCAGAATTTTTTGGTGTGACGTT
GTCGGATTTGTTAAAAAGCTATTCAATGGAGCAGTTAGAAGATGAGTACGATAAACAAACAGCAGAAATTGCTCACAAAC
GATGGATTGAGCAAGGAAAAGAAACAATTTCTATGGACGAAATATTAAATGAGTTTGGTGGATTATAA

Structures

Antitoxin

• AlphaFold DB: R3JPM7