Detailed information of TA system TA088043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 81979..82610
• Replicon: plasmid unnamed
• Accession: NZ_CP024584
• Organism: Roseomonas sp. FDAARGOS_362

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CTJ15_RS03460
• Protein ID: WP_099781146.1
• Coordinates: 82200..82610 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2D2H0A1
• Locus tag: CTJ15_RS03455
• Protein ID: WP_027283136.1
• Coordinates: 81979..82203 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTJ15_RS03440	77787..79133	-	1347	WP_099780965.1	IS5 family transposase	-
CTJ15_RS03445	79258..80184	+	927	WP_099781144.1	DNA/RNA non-specific endonuclease	-
CTJ15_RS03450	80748..81866	+	1119	WP_099781145.1	site-specific integrase	-
CTJ15_RS03455	81979..82203	+	225	WP_027283136.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CTJ15_RS03460	82200..82610	+	411	WP_099781146.1	type II toxin-antitoxin system VapC family toxin	Toxin
CTJ15_RS03465	82835..85672	+	2838	WP_099781147.1	DEAD/DEAH box helicase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..127617	127617
	-	flank	IS/Tn	-	-	77787..79169	1382

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-117)

Antitoxin

• SpoVT-AbrB domain (9-45)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15093.18 Da
• Isoelectric Point: 5.3035

>T88043 WP_099781146.1 NZ_CP024584:82200-82610 [Roseomonas sp. FDAARGOS_362]
VTLRYLLDTNLCIRVLRDRPAGLRERFNAEAAALCTSDVVLYELLYGAERSARPAETRREVERFVARLSVLPFDDDAAAH
TAEIRASLERRGGVIGPYDLMIAGQARSRGLVVVTGNLSEFGRVEGLRCEDWLADA

Nucleotide

• Length: 411 bp

>T88043 NZ_CP024584:82200-82610 [Roseomonas sp. FDAARGOS_362]
GTGACGCTGCGCTACCTGCTCGACACCAACCTGTGCATCCGGGTGCTGCGCGACCGTCCGGCCGGTCTGCGGGAGCGTTT
CAACGCGGAGGCCGCGGCGCTCTGCACCTCGGACGTGGTGCTCTACGAGCTGCTCTACGGGGCGGAGCGCTCGGCCCGGC
CCGCCGAGACGCGGCGCGAGGTGGAGCGCTTCGTGGCCAGGCTGAGCGTGCTGCCCTTCGACGATGACGCGGCGGCGCAC
ACGGCCGAGATCCGGGCGAGCCTGGAGCGGCGAGGCGGGGTGATCGGTCCCTACGACCTGATGATCGCGGGCCAGGCGCG
CAGCCGCGGGCTGGTGGTGGTGACGGGCAACCTGAGCGAGTTTGGCCGGGTGGAGGGGCTGCGCTGCGAGGACTGGCTGG
CTGACGCATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8189.41 Da
• Isoelectric Point: 9.1096

>AT88043 WP_027283136.1 NZ_CP024584:81979-82203 [Roseomonas sp. FDAARGOS_362]
MPARTTLFLSNRSQAVRLPKGVAFGEGVREVVILRDGPRRVIAPADALWDDFFAGPGLDLGERRQPAMQEREAL

Nucleotide

• Length: 225 bp

>AT88043 NZ_CP024584:81979-82203 [Roseomonas sp. FDAARGOS_362]
ATGCCCGCCCGCACGACCCTGTTCCTGTCCAACCGCTCCCAGGCCGTGCGCCTGCCCAAGGGCGTGGCCTTCGGCGAGGG
GGTGCGCGAGGTGGTGATCCTGCGCGACGGCCCCCGCCGCGTCATCGCCCCGGCCGATGCACTGTGGGACGACTTCTTCG
CGGGCCCTGGCCTGGACCTCGGCGAGCGGCGGCAGCCGGCGATGCAGGAACGCGAGGCGCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2D2H0A1