Detailed information of TA system TA088040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1294751..1295430
• Replicon: chromosome
• Accession: NZ_CP024576
• Organism: Acinetobacter baumannii strain AbPK1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: CTI08_RS06180
• Protein ID: WP_000838146.1
• Coordinates: 1294751..1294933 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: CTI08_RS06185
• Protein ID: WP_000966688.1
• Coordinates: 1295026..1295430 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTI08_RS06140	1289995..1290393	+	399	WP_025466443.1	hypothetical protein	-
CTI08_RS06145	1290395..1290613	+	219	WP_001277693.1	hypothetical protein	-
CTI08_RS06150	1290722..1291242	+	521	Protein_1178	SH3 domain-containing protein	-
CTI08_RS06155	1291339..1291692	+	354	WP_099714904.1	hypothetical protein	-
CTI08_RS06160	1291692..1292870	+	1179	WP_099714906.1	phage tail protein	-
CTI08_RS06165	1292923..1293840	+	918	WP_099714908.1	hypothetical protein	-
CTI08_RS06170	1293910..1294425	+	516	WP_099714910.1	hypothetical protein	-
CTI08_RS06180	1294751..1294933	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
CTI08_RS06185	1295026..1295430	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CTI08_RS06190	1295530..1296039	+	510	WP_000735548.1	hypothetical protein	-
CTI08_RS06195	1296110..1300288	+	4179	Protein_1186	tape measure protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1260372..1308271	47899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T88040 WP_000838146.1 NZ_CP024576:1294751-1294933 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T88040 NZ_CP024576:1294751-1294933 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT88040 WP_000966688.1 NZ_CP024576:1295026-1295430 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT88040 NZ_CP024576:1295026-1295430 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6