Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4732812..4733328 Replicon chromosome
Accession NZ_CP024563
Organism Klebsiella pneumoniae strain INF278

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag CTI68_RS23850 Protein ID WP_002886902.1
Coordinates 4732812..4733096 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CTI68_RS23855 Protein ID WP_002886901.1
Coordinates 4733086..4733328 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTI68_RS23830 4728296..4728604 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
CTI68_RS30330 4728689..4728862 + 174 WP_002886906.1 hypothetical protein -
CTI68_RS23835 4728865..4729608 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CTI68_RS23840 4729965..4732103 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CTI68_RS23845 4732344..4732808 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CTI68_RS23850 4732812..4733096 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CTI68_RS23855 4733086..4733328 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CTI68_RS23860 4733406..4735316 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CTI68_RS23865 4735339..4736493 - 1155 WP_002886900.1 lactonase family protein -
CTI68_RS23870 4736559..4737299 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T88012 WP_002886902.1 NZ_CP024563:c4733096-4732812 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T88012 NZ_CP024563:c4733096-4732812 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT88012 WP_002886901.1 NZ_CP024563:c4733328-4733086 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT88012 NZ_CP024563:c4733328-4733086 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References