Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4788877..4789393 Replicon chromosome
Accession NZ_CP024548
Organism Klebsiella pneumoniae strain KSB1_7J

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag CTI66_RS24110 Protein ID WP_004192395.1
Coordinates 4788877..4789161 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag CTI66_RS24115 Protein ID WP_004192397.1
Coordinates 4789151..4789393 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTI66_RS24090 4784294..4784602 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
CTI66_RS27700 4784687..4784860 + 174 WP_002886906.1 hypothetical protein -
CTI66_RS24095 4784863..4785606 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CTI66_RS24100 4785963..4788101 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CTI66_RS24105 4788409..4788873 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CTI66_RS24110 4788877..4789161 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CTI66_RS24115 4789151..4789393 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CTI66_RS24120 4789471..4791381 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CTI66_RS24125 4791404..4792558 - 1155 WP_004178372.1 lactonase family protein -
CTI66_RS24130 4792625..4793365 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T87952 WP_004192395.1 NZ_CP024548:c4789161-4788877 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T87952 NZ_CP024548:c4789161-4788877 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT87952 WP_004192397.1 NZ_CP024548:c4789393-4789151 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT87952 NZ_CP024548:c4789393-4789151 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References