Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 6572..7308 Replicon plasmid unnamed1
Accession NZ_CP024543
Organism Klebsiella pneumoniae strain INF042

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag CTI63_RS26905 Protein ID WP_004098919.1
Coordinates 6572..7054 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A455TK27
Locus tag CTI63_RS26910 Protein ID WP_020804426.1
Coordinates 7042..7308 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTI63_RS26880 2009..2437 - 429 WP_001554382.1 GFA family protein -
CTI63_RS26885 2631..3626 - 996 WP_025714249.1 IS110 family transposase -
CTI63_RS26890 4033..4491 + 459 WP_077252872.1 hypothetical protein -
CTI63_RS26895 4508..5371 + 864 WP_020803592.1 toll/interleukin-1 receptor domain-containing protein -
CTI63_RS26900 5653..6369 - 717 Protein_6 IS3-like element ISKpn38 family transposase -
CTI63_RS26905 6572..7054 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
CTI63_RS26910 7042..7308 - 267 WP_020804426.1 DUF1778 domain-containing protein Antitoxin
CTI63_RS26915 7484..7738 - 255 WP_032425571.1 hypothetical protein -
CTI63_RS26920 7814..8071 - 258 WP_004098928.1 hypothetical protein -
CTI63_RS26925 8120..8323 - 204 WP_004150739.1 hemolysin expression modulator Hha -
CTI63_RS26930 8384..8878 - 495 WP_016528789.1 hypothetical protein -
CTI63_RS26935 8909..9475 - 567 WP_009654312.1 hypothetical protein -
CTI63_RS26940 9472..9735 - 264 WP_004118691.1 hypothetical protein -
CTI63_RS26945 10049..10228 + 180 WP_004118349.1 type II toxin-antitoxin system ParD family antitoxin -
CTI63_RS26950 10215..10313 + 99 WP_004118688.1 type II toxin-antitoxin system RelE/ParE family toxin -
CTI63_RS26960 10692..11126 - 435 WP_004118347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..110374 110374
- flank IS/Tn - - 5653..6315 662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T87912 WP_004098919.1 NZ_CP024543:c7054-6572 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T87912 NZ_CP024543:c7054-6572 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGTGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10124.47 Da        Isoelectric Point: 4.3108

>AT87912 WP_020804426.1 NZ_CP024543:c7308-7042 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINELL
ARKPQWDV

Download         Length: 267 bp

>AT87912 NZ_CP024543:c7308-7042 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCCCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATGAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A455TK27

References