87908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4685516..4686186 Replicon chromosome
Accession NZ_CP024542
Organism Klebsiella pneumoniae strain INF042

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag CTI63_RS23615 Protein ID WP_023301398.1
Coordinates 4685516..4685848 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag CTI63_RS23620 Protein ID WP_023301397.1
Coordinates 4685869..4686186 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CTI63_RS23590 4680741..4681413 + 673 Protein_4474 DUF4400 domain-containing protein -
CTI63_RS23595 4681424..4682308 + 885 WP_004192285.1 RES domain-containing protein -
CTI63_RS23600 4682507..4682695 - 189 Protein_4476 transposase -
CTI63_RS23605 4682712..4683823 - 1112 Protein_4477 IS3 family transposase -
CTI63_RS23610 4684222..4685121 - 900 WP_077253334.1 hypothetical protein -
CTI63_RS23615 4685516..4685848 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
CTI63_RS23620 4685869..4686186 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CTI63_RS23625 4686205..4686426 - 222 WP_023301396.1 DUF987 domain-containing protein -
CTI63_RS23630 4686435..4686917 - 483 WP_023301395.1 RadC family protein -
CTI63_RS23635 4686926..4687384 - 459 WP_023301394.1 antirestriction protein -
CTI63_RS23640 4687470..4687706 - 237 WP_032446575.1 DUF905 domain-containing protein -
CTI63_RS23645 4687784..4688194 - 411 WP_023301393.1 hypothetical protein -
CTI63_RS23650 4688261..4688698 - 438 WP_023301392.1 hypothetical protein -
CTI63_RS23655 4688740..4689276 - 537 WP_023301391.1 DUF4339 domain-containing protein -
CTI63_RS23660 4689302..4690012 - 711 WP_023301390.1 DeoR family transcriptional regulator -
CTI63_RS23665 4690221..4691045 - 825 WP_023301389.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T87908 WP_023301398.1 NZ_CP024542:c4685848-4685516 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T87908 NZ_CP024542:c4685848-4685516 [Klebsiella pneumoniae]
ATGAAAACTTTACCTGCAACAACTCCGCAGACGGCGAAGCTATGTCTGACGTCCGCGGATACCTGGCAAATGTTACTGAC
ACGTCTGCTAGAACAGCATTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATTG
ATGCAGGGATCCCTCTGGCCGATGCAGTTAACTTTCTGGTGGATAAGTACGCACTGGTTCGTATCGATCGCAGAGGATTG
AGTTGGCAGGAGCAATCATCCTATCTCCGGCTTGTCGATACTCAGCGAACCATTAAGGTTATTGAGTTGTGGCTATTTGG
TGTAATGATGTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT87908 WP_023301397.1 NZ_CP024542:c4686186-4685869 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT87908 NZ_CP024542:c4686186-4685869 [Klebsiella pneumoniae]
ATGAGCAACATCACTTGGGGCCTGCAGCGGGATATCACGCCGTGCCTGGGATCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGAGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGTTGGATGTCGTATTTCCAC
ATTTTATCAGTCAGATGGAATCGATGTTGACCACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTCCGGCTACGTATACATCGCTGTTTATCTCACCCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References