Detailed information of TA system TA087828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 29610..30520
• Replicon: plasmid unnamed1
• Accession: NZ_CP024497
• Organism: Klebsiella pneumoniae strain KSB1_7E

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A663AYG0
• Locus tag: CTI55_RS26310
• Protein ID: WP_004026354.1
• Coordinates: 30050..30520 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: CTI55_RS26305
• Protein ID: WP_099745242.1
• Coordinates: 29610..30053 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTI55_RS26280	25980..26393	+	414	WP_099745240.1	NB-ARC domain protein	-
CTI55_RS26285	26456..27130	+	675	Protein_39	hypothetical protein	-
CTI55_RS26290	27130..27462	+	333	Protein_40	transposase	-
CTI55_RS26295	27816..28238	+	423	WP_004197884.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
CTI55_RS26300	28238..29509	+	1272	WP_099745241.1	translesion error-prone DNA polymerase V subunit UmuC	-
CTI55_RS26305	29610..30053	+	444	WP_099745242.1	DUF2384 domain-containing protein	Antitoxin
CTI55_RS26310	30050..30520	+	471	WP_004026354.1	RES family NAD+ phosphorylase	Toxin
CTI55_RS26315	30631..30891	-	261	WP_004026352.1	hypothetical protein	-
CTI55_RS26325	31615..31773	+	159	WP_004181898.1	type I toxin-antitoxin system Hok family toxin	-
CTI55_RS26330	32152..32394	-	243	WP_086528906.1	hypothetical protein	-
CTI55_RS27990	32424..32591	-	168	WP_196241044.1	hypothetical protein	-
CTI55_RS27995	32980..33954	+	975	WP_196241043.1	Hok/Gef family protein	-
CTI55_RS26345	34152..34529	-	378	WP_099745244.1	phosphonate ABC transporter substrate-binding protein	-
CTI55_RS26355	34856..35152	+	297	WP_099745245.1	hydrogenase expression/formation protein HypD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	pla	1..212097	212097

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre (16-147)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17515.79 Da
• Isoelectric Point: 4.6155

>T87828 WP_004026354.1 NZ_CP024497:30050-30520 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

>T87828 NZ_CP024497:30050-30520 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGTTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACTCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16494.83 Da
• Isoelectric Point: 10.2498

>AT87828 WP_099745242.1 NZ_CP024497:29610-30053 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPAELMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT87828 NZ_CP024497:29610-30053 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTTCGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGAGCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A663AYG0