Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 782757..783414 Replicon chromosome
Accession NZ_CP024496
Organism Klebsiella pneumoniae strain KSB1_7E

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CTI55_RS04015 Protein ID WP_002916310.1
Coordinates 783004..783414 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CTI55_RS04010 Protein ID WP_002916312.1
Coordinates 782757..783023 (+) Length 89 a.a.

Genomic Context


CTI55_RS03995CTI55_RS04000CTI55_RS04010CTI55_RS04015CTI55_RS04025CTI55_RS04030CTI55_RS04035CTI55_RS03985CTI55_RS03990CTI55_RS04005CTI55_RS04020
Location: 780295..780606 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Location: 780770..781429 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 782757..783023 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 783004..783414 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 784043..784939 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 784962..785675 (714 bp)
Type: Others
Protein ID: WP_002916301.1
Location: 785681..787414 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Location: 777965..779398 (1434 bp)
Type: Others
Protein ID: WP_004185559.1
Location: 779517..780245 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 781528..782511 (984 bp)
Type: Others
Protein ID: WP_002916313.1
Location: 783421..783942 (522 bp)
Type: Others
Protein ID: WP_004144730.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CTI55_RS03985777965..779398-1434WP_004185559.16-phospho-beta-glucosidase BglA-
CTI55_RS03990779517..780245-729WP_002916321.1MurR/RpiR family transcriptional regulator-
CTI55_RS03995780295..780606+312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
CTI55_RS04000780770..781429+660WP_002916317.1hemolysin III family protein-
CTI55_RS04005781528..782511-984WP_002916313.1tRNA-modifying protein YgfZ-
CTI55_RS04010782757..783023+267WP_002916312.1FAD assembly factor SdhEAntitoxin
CTI55_RS04015783004..783414+411WP_002916310.1protein YgfXToxin
CTI55_RS04020783421..783942-522WP_004144730.1flavodoxin FldB-
CTI55_RS04025784043..784939+897WP_004144729.1site-specific tyrosine recombinase XerD-
CTI55_RS04030784962..785675+714WP_002916301.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
CTI55_RS04035785681..787414+1734WP_004149758.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T87812 WP_002916310.1 NZ_CP024496:783004-783414 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T87812 NZ_CP024496:783004-783414 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT87812 WP_002916312.1 NZ_CP024496:782757-783023 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87812 NZ_CP024496:782757-783023 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References