Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4074191..4075023 Replicon chromosome
Accession NZ_CP024479
Organism Escherichia coli strain 2011C-4315

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag A5958_RS21875 Protein ID WP_000854753.1
Coordinates 4074191..4074565 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9QGA8
Locus tag A5958_RS21880 Protein ID WP_001280948.1
Coordinates 4074655..4075023 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5958_RS21840 4069335..4069973 + 639 WP_001145628.1 DUF1076 domain-containing protein -
A5958_RS21845 4070264..4071628 + 1365 WP_000953522.1 EspK/GogB family type III secretion system effector -
A5958_RS21860 4072831..4073400 - 570 WP_001290252.1 DUF4942 domain-containing protein -
A5958_RS21865 4073497..4073694 - 198 WP_000839281.1 DUF957 domain-containing protein -
A5958_RS21870 4073706..4074194 - 489 WP_000777552.1 hypothetical protein -
A5958_RS21875 4074191..4074565 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
A5958_RS21880 4074655..4075023 - 369 WP_001280948.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A5958_RS21885 4075186..4075407 - 222 WP_000692311.1 DUF987 domain-containing protein -
A5958_RS21890 4075470..4075946 - 477 WP_001186726.1 RadC family protein -
A5958_RS21895 4075962..4076447 - 486 WP_000849571.1 antirestriction protein -
A5958_RS21900 4076502..4077320 - 819 WP_001234620.1 DUF945 domain-containing protein -
A5958_RS21910 4077420..4077653 - 234 WP_001119729.1 DUF905 family protein -
A5958_RS21915 4077732..4078103 - 372 WP_064758448.1 hypothetical protein -
A5958_RS21920 4078141..4079354 + 1214 WP_162860179.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T87776 WP_000854753.1 NZ_CP024479:c4074565-4074191 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T87776 NZ_CP024479:c4074565-4074191 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13609.50 Da        Isoelectric Point: 7.3991

>AT87776 WP_001280948.1 NZ_CP024479:c4075023-4074655 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT87776 NZ_CP024479:c4075023-4074655 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QGA8

References