Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2739777..2740612 Replicon chromosome
Accession NZ_CP024479
Organism Escherichia coli strain 2011C-4315

Toxin (Protein)


Gene name yeeV Uniprot ID F2VI91
Locus tag A5958_RS14970 Protein ID WP_000854748.1
Coordinates 2740235..2740612 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H0IVG5
Locus tag A5958_RS14965 Protein ID WP_001339471.1
Coordinates 2739777..2740145 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5958_RS14930 2736613..2737068 + 456 WP_000581504.1 hypothetical protein -
A5958_RS14935 2737147..2737380 + 234 WP_001119729.1 DUF905 family protein -
A5958_RS14945 2737480..2738298 + 819 WP_001234620.1 DUF945 domain-containing protein -
A5958_RS14950 2738353..2738838 + 486 WP_000849570.1 antirestriction protein -
A5958_RS14955 2738854..2739330 + 477 WP_001186727.1 RadC family protein -
A5958_RS14960 2739393..2739614 + 222 WP_000692345.1 DUF987 domain-containing protein -
A5958_RS14965 2739777..2740145 + 369 WP_001339471.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A5958_RS14970 2740235..2740612 + 378 WP_000854748.1 TA system toxin CbtA family protein Toxin
A5958_RS14975 2740609..2741097 + 489 WP_000761721.1 hypothetical protein -
A5958_RS14980 2741109..2741306 + 198 WP_000839281.1 DUF957 domain-containing protein -
A5958_RS14985 2741403..2741975 + 573 WP_001290246.1 DUF4942 domain-containing protein -
A5958_RS14995 2742724..2744262 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14179.16 Da        Isoelectric Point: 7.7761

>T87770 WP_000854748.1 NZ_CP024479:2740235-2740612 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T87770 NZ_CP024479:2740235-2740612 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13517.22 Da        Isoelectric Point: 6.4789

>AT87770 WP_001339471.1 NZ_CP024479:2739777-2740145 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT87770 NZ_CP024479:2739777-2740145 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F2VI91

Antitoxin

Source ID Structure
AlphaFold DB A0A0H0IVG5

References