Detailed information of TA system TA087764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1279784..1280262
• Replicon: chromosome
• Accession: NZ_CP024479
• Organism: Escherichia coli strain 2011C-4315

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: A5958_RS07450
• Protein ID: WP_001303876.1
• Coordinates: 1279975..1280262 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: A5958_RS07445
• Protein ID: WP_000536233.1
• Coordinates: 1279784..1279975 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A5958_RS07410	1275164..1275934	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
A5958_RS07415	1276016..1276702	-	687	WP_000788749.1	ATP-binding protein	-
A5958_RS07420	1276709..1277824	-	1116	WP_001205820.1	hypothetical protein	-
A5958_RS07425	1277903..1278358	+	456	WP_000273724.1	hypothetical protein	-
A5958_RS07430	1278565..1278990	-	426	WP_000693855.1	Rha family transcriptional regulator	-
A5958_RS07435	1278974..1279246	-	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
A5958_RS07440	1279355..1279756	+	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
A5958_RS07445	1279784..1279975	+	192	WP_000536233.1	hypothetical protein	Antitoxin
A5958_RS07450	1279975..1280262	+	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A5958_RS07455	1280539..1280694	+	156	WP_000379575.1	DUF1391 family protein	-
A5958_RS07465	1280836..1281225	+	390	WP_000394513.1	hypothetical protein	-
A5958_RS07470	1281412..1281597	-	186	WP_001133046.1	hypothetical protein	-
A5958_RS07480	1282171..1282359	+	189	WP_000413705.1	cell division inhibition protein DicB	-
A5958_RS07485	1282356..1282547	+	192	WP_001098307.1	DUF1482 family protein	-
A5958_RS07490	1282641..1285112	+	2472	WP_000034468.1	exonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1271976..1293774	21798

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T87764 WP_001303876.1 NZ_CP024479:1279975-1280262 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T87764 NZ_CP024479:1279975-1280262 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT87764 WP_000536233.1 NZ_CP024479:1279784-1279975 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT87764 NZ_CP024479:1279784-1279975 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA