87745

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 152832..153337 Replicon chromosome
Accession NZ_CP024477
Organism Pseudomonas aeruginosa strain 12939

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CS058_RS00715 Protein ID WP_003083773.1
Coordinates 152832..153113 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag CS058_RS00720 Protein ID WP_003137009.1
Coordinates 153110..153337 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS058_RS00690 148083..149432 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
CS058_RS00695 149481..150167 + 687 WP_003083762.1 FadR family transcriptional regulator -
CS058_RS00700 150268..151002 + 735 WP_023107524.1 GntR family transcriptional regulator -
CS058_RS00705 151206..151592 + 387 WP_003083767.1 aegerolysin family protein -
CS058_RS00710 151624..152532 - 909 WP_023436116.1 LysR family transcriptional regulator -
CS058_RS00715 152832..153113 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CS058_RS00720 153110..153337 - 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
CS058_RS00725 153513..154133 - 621 WP_099887524.1 hypothetical protein -
CS058_RS00730 154234..154734 + 501 WP_003101228.1 LEA type 2 family protein -
CS058_RS00735 154807..155148 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CS058_RS00740 155233..156660 - 1428 WP_023092260.1 GABA permease -
CS058_RS00745 156829..158322 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T87745 WP_003083773.1 NZ_CP024477:c153113-152832 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T87745 NZ_CP024477:c153113-152832 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT87745 WP_003137009.1 NZ_CP024477:c153337-153110 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT87745 NZ_CP024477:c153337-153110 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References