Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 106078..106637 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP024476 | ||
| Organism | Shigella flexneri 7b strain 94-3007 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2AJT2 |
| Locus tag | CPZ98_RS24950 | Protein ID | WP_000421262.1 |
| Coordinates | 106078..106353 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | CPZ98_RS24955 | Protein ID | WP_024260696.1 |
| Coordinates | 106353..106637 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ98_RS24920 | 102954..103061 | - | 108 | WP_023592908.1 | transposase domain-containing protein | - |
| CPZ98_RS24925 | 103085..103390 | - | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | - |
| CPZ98_RS24930 | 103392..103610 | - | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| CPZ98_RS24935 | 104146..105099 | - | 954 | Protein_124 | IS66 family transposase | - |
| CPZ98_RS24940 | 105155..105852 | + | 698 | WP_223368647.1 | IS1 family transposase | - |
| CPZ98_RS24950 | 106078..106353 | - | 276 | WP_000421262.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ98_RS24955 | 106353..106637 | - | 285 | WP_024260696.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| CPZ98_RS24965 | 107089..107340 | + | 252 | WP_001381727.1 | transporter | - |
| CPZ98_RS24970 | 107390..107599 | + | 210 | Protein_129 | peptidoglycan-binding protein | - |
| CPZ98_RS24975 | 107699..107884 | - | 186 | Protein_130 | ATP-binding protein | - |
| CPZ98_RS24980 | 108073..109674 | - | 1602 | WP_134797205.1 | IS66-like element ISSfl3 family transposase | - |
| CPZ98_RS24985 | 109671..110021 | - | 351 | WP_005061851.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CPZ98_RS24990 | 110018..110692 | - | 675 | WP_004967157.1 | IS66-like element accessory protein TnpA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ipaH7.8 / ospC2 / ipaH2.5 / ospE2 / ipgB2 / ospD1 / ospF / ospD2 / ospB / icsP/sopA / nleE / ospE1 / ipaH1.4 / ospG / ipaH9.8 / ospI / papC / icsA/virG / virA / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ospC1 / ospD3/senA / ipaH4.5 | 1..220282 | 220282 | |
| - | inside | IScluster/Tn | - | ospG / ipaH9.8 / ospI | 96518..118232 | 21714 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10766.48 Da Isoelectric Point: 9.9324
>T87743 WP_000421262.1 NZ_CP024476:c106353-106078 [Shigella flexneri 7b]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T87743 NZ_CP024476:c106353-106078 [Shigella flexneri 7b]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10513.93 Da Isoelectric Point: 6.2150
>AT87743 WP_024260696.1 NZ_CP024476:c106637-106353 [Shigella flexneri 7b]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQSW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQSW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT87743 NZ_CP024476:c106637-106353 [Shigella flexneri 7b]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGTCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGTCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|