Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 103085..103610 Replicon plasmid unnamed3
Accession NZ_CP024476
Organism Shigella flexneri 7b strain 94-3007

Toxin (Protein)


Gene name ccdB Uniprot ID Q326Z8
Locus tag CPZ98_RS24925 Protein ID WP_001159860.1
Coordinates 103085..103390 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID Q7BEK0
Locus tag CPZ98_RS24930 Protein ID WP_000813626.1
Coordinates 103392..103610 (-) Length 73 a.a.

Genomic Context

CPZ98_RS24940CPZ98_RS24965CPZ98_RS24970CPZ98_RS26140CPZ98_RS24900CPZ98_RS26715CPZ98_RS24910CPZ98_RS24915CPZ98_RS24920CPZ98_RS24925CPZ98_RS24930CPZ98_RS24935CPZ98_RS24950CPZ98_RS24955CPZ98_RS24975
Location: 105155..105852 (698 bp)
Type: Others
Protein ID: WP_223368647.1
Location: 107089..107340 (252 bp)
Type: Others
Protein ID: WP_001381727.1
Location: 107390..107599 (210 bp)
Type: Others
Protein ID: Protein_129
Location: 99115..99381 (267 bp)
Type: Others
Protein ID: Protein_116
Location: 99736..100326 (591 bp)
Type: Others
Protein ID: WP_000705601.1
Location: 100409..100578 (170 bp)
Type: Others
Protein ID: Protein_118
Location: 100578..100847 (270 bp)
Type: Others
Protein ID: Protein_119
Location: 101055..102692 (1638 bp)
Type: Others
Protein ID: WP_000936806.1
Location: 102954..103061 (108 bp)
Type: Others
Protein ID: WP_023592908.1
Location: 103085..103390 (306 bp)
Type: Toxin
Protein ID: WP_001159860.1
Location: 103392..103610 (219 bp)
Type: Antitoxin
Protein ID: WP_000813626.1
Location: 104146..105099 (954 bp)
Type: Others
Protein ID: Protein_124
Location: 106078..106353 (276 bp)
Type: Others
Protein ID: WP_000421262.1
Location: 106353..106637 (285 bp)
Type: Others
Protein ID: WP_024260696.1
Location: 107699..107884 (186 bp)
Type: Others
Protein ID: Protein_130
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPZ98_RS2614099115..99381-267Protein_116IS66 family insertion sequence element accessory protein TnpB-
CPZ98_RS2490099736..100326-591WP_000705601.1type III secretion system effector protein kinase OspG-
CPZ98_RS26715100409..100578-170Protein_118type II toxin-antitoxin system toxin YacB-
CPZ98_RS24910100578..100847-270Protein_119type II toxin-antitoxin system antitoxin YacA-
CPZ98_RS24915101055..102692-1638WP_000936806.1T3SS effector E3 ubiquitin-protein ligase IpaH9.8-
CPZ98_RS24920102954..103061-108WP_023592908.1transposase domain-containing protein-
CPZ98_RS24925103085..103390-306WP_001159860.1type II toxin-antitoxin system toxin CcdBToxin
CPZ98_RS24930103392..103610-219WP_000813626.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
CPZ98_RS24935104146..105099-954Protein_124IS66 family transposase-
CPZ98_RS24940105155..105852+698WP_223368647.1IS1 family transposase-
CPZ98_RS24950106078..106353-276WP_000421262.1type II toxin-antitoxin system RelE/ParE family toxin-
CPZ98_RS24955106353..106637-285WP_024260696.1ribbon-helix-helix domain-containing protein-
CPZ98_RS24965107089..107340+252WP_001381727.1transporter-
CPZ98_RS24970107390..107599+210Protein_129peptidoglycan-binding protein-
CPZ98_RS24975107699..107884-186Protein_130ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-ipaH7.8 / ospC2 / ipaH2.5 / ospE2 / ipgB2 / ospD1 / ospF / ospD2 / ospB / icsP/sopA / nleE / ospE1 / ipaH1.4 / ospG / ipaH9.8 / ospI / papC / icsA/virG / virA / spa40 / spa29 / spa9 / spa24 / spa33 / spa32 / spa13 / spa47 / spa15 / mxiA / mxiC / mxiD / mxiE / mxiM / mxiL / mxiN / mxiK / mxiJ / mxiI / mxiH / mxiG / ipgF / ipgE / ipgD / icsB / ipgA / ipgB1 / ipgC / ipaB / ipaC / ipaD / ipaA / ipaJ / ospC3 / ospC1 / ospD3/senA / ipaH4.51..220282220282
-insideIScluster/Tn-ospG / ipaH9.8 / ospI96518..11823221714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11736.59 Da        Isoelectric Point: 6.4674

>T87742 WP_001159860.1 NZ_CP024476:c103390-103085 [Shigella flexneri 7b]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPIFVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T87742 NZ_CP024476:c103390-103085 [Shigella flexneri 7b]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTACAGAGTGACATTATTGACAC
GCCCGGACGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACTGATATGGCCAGTGTGCCGATCTTCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8333.36 Da        Isoelectric Point: 6.2838

>AT87742 WP_000813626.1 NZ_CP024476:c103610-103392 [Shigella flexneri 7b]
MKQRITVTIDSDSYQLLKSANVNISGLVNTAMQKEARRLRAERWQAENQQGMAEIARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT87742 NZ_CP024476:c103610-103392 [Shigella flexneri 7b]
ATGAAGCAGCGTATTACTGTCACTATAGACAGTGACAGCTATCAGTTACTTAAATCCGCAAACGTGAATATCTCAGGCCT
GGTAAATACGGCCATGCAAAAAGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCTGAAAATCAGCAGGGGATGGCTG
AGATCGCCCGTTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7TTN3

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7BEK0

References