Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3544287..3544813 Replicon chromosome
Accession NZ_CP024473
Organism Shigella flexneri 7b strain 94-3007

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CPZ98_RS18020 Protein ID WP_000323025.1
Coordinates 3544526..3544813 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CPZ98_RS18015 Protein ID WP_000534858.1
Coordinates 3544287..3544526 (+) Length 80 a.a.

Genomic Context

CPZ98_RS18000CPZ98_RS18005CPZ98_RS18015CPZ98_RS18020CPZ98_RS18025CPZ98_RS18030CPZ98_RS18035CPZ98_RS18040CPZ98_RS18045CPZ98_RS18050CPZ98_RS18070CPZ98_RS17995CPZ98_RS18010CPZ98_RS18075
Location: 3542367..3543064 (698 bp)
Type: Others
Protein ID: WP_232046037.1
Location: 3543082..3543960 (879 bp)
Type: Others
Protein ID: Protein_3463
Location: 3544287..3544526 (240 bp)
Type: Antitoxin
Protein ID: WP_000534858.1
Location: 3544526..3544813 (288 bp)
Type: Toxin
Protein ID: WP_000323025.1
Location: 3544885..3545040 (156 bp)
Type: Others
Protein ID: WP_000813254.1
Location: 3545258..3545473 (216 bp)
Type: Others
Protein ID: WP_000980986.1
Location: 3545576..3545854 (279 bp)
Type: Others
Protein ID: Protein_3469
Location: 3545856..3546905 (1050 bp)
Type: Others
Protein ID: WP_001265249.1
Location: 3546918..3547274 (357 bp)
Type: Others
Protein ID: WP_000904111.1
Location: 3547289..3548110 (822 bp)
Type: Others
Protein ID: WP_000762884.1
Location: 3549031..3549139 (109 bp)
Type: Others
Protein ID: Protein_3473
Location: 3541882..3542310 (429 bp)
Type: Others
Protein ID: Protein_3461
Location: 3543957..3544262 (306 bp)
Type: Others
Protein ID: WP_071818640.1
Location: 3549420..3549755 (336 bp)
Type: Others
Protein ID: WP_000871291.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPZ98_RS17995 (3541882)3541882..3542310-429Protein_3461fimbrial protein-
CPZ98_RS18000 (3542367)3542367..3543064+698WP_232046037.1IS1 family transposase-
CPZ98_RS18005 (3543082)3543082..3543960+879Protein_3463IS3-like element IS600 family transposase-
CPZ98_RS18010 (3543957)3543957..3544262-306WP_071818640.1hypothetical protein-
CPZ98_RS18015 (3544287)3544287..3544526+240WP_000534858.1type II toxin-antitoxin system antitoxin RelBAntitoxin
CPZ98_RS18020 (3544526)3544526..3544813+288WP_000323025.1type II toxin-antitoxin system mRNA interferase RelEToxin
CPZ98_RS18025 (3544885)3544885..3545040+156WP_000813254.1type I toxin-antitoxin system toxin HokD-
CPZ98_RS18030 (3545258)3545258..3545473+216WP_000980986.1hypothetical protein-
CPZ98_RS18035 (3545576)3545576..3545854+279Protein_3469hypothetical protein-
CPZ98_RS18040 (3545856)3545856..3546905+1050WP_001265249.1DUF968 domain-containing protein-
CPZ98_RS18045 (3546918)3546918..3547274+357WP_000904111.1RusA family crossover junction endodeoxyribonuclease-
CPZ98_RS18050 (3547289)3547289..3548110+822WP_000762884.1antitermination protein-
CPZ98_RS18070 (3549031)3549031..3549139+109Protein_3473DUF3927 family protein-
CPZ98_RS18075 (3549420)3549420..3549755-336WP_000871291.1anti-adapter protein IraM-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3536923..356124924326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T87722 WP_000323025.1 NZ_CP024473:3544526-3544813 [Shigella flexneri 7b]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T87722 NZ_CP024473:3544526-3544813 [Shigella flexneri 7b]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT87722 WP_000534858.1 NZ_CP024473:3544287-3544526 [Shigella flexneri 7b]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT87722 NZ_CP024473:3544287-3544526 [Shigella flexneri 7b]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB4V7K
PDB4V7J
PDB4FXI
PDB4FXE
PDB2KC8
PDB4FXH
PDB2KC9

Antitoxin

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Source
ID
Structure
PDB4FXE
PDB2KC8
PDB2K29
AlphaFold DBA0A4V1CTS8

References