Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3054136..3054931 | Replicon | chromosome |
| Accession | NZ_CP024473 | ||
| Organism | Shigella flexneri 7b strain 94-3007 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | CPZ98_RS15320 | Protein ID | WP_000854917.1 |
| Coordinates | 3054557..3054931 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | CPZ98_RS15315 | Protein ID | WP_001280958.1 |
| Coordinates | 3054136..3054510 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ98_RS15275 (3050025) | 3050025..3050722 | + | 698 | WP_103215986.1 | IS1-like element IS1A family transposase | - |
| CPZ98_RS26460 (3050926) | 3050926..3051168 | + | 243 | WP_000348966.1 | DNA polymerase III subunit gamma/tau | - |
| CPZ98_RS15285 (3051288) | 3051288..3051461 | + | 174 | WP_000088744.1 | DUF905 family protein | - |
| CPZ98_RS15290 (3051561) | 3051561..3052382 | + | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| CPZ98_RS15300 (3052724) | 3052724..3053197 | + | 474 | WP_005011597.1 | antirestriction protein | - |
| CPZ98_RS15305 (3053213) | 3053213..3053689 | + | 477 | WP_005011624.1 | RadC family protein | - |
| CPZ98_RS15310 (3053752) | 3053752..3053973 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| CPZ98_RS15315 (3054136) | 3054136..3054510 | + | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CPZ98_RS15320 (3054557) | 3054557..3054931 | + | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| CPZ98_RS15325 (3054928) | 3054928..3055419 | + | 492 | WP_130862204.1 | DUF5983 family protein | - |
| CPZ98_RS15330 (3055431) | 3055431..3055628 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| CPZ98_RS15335 (3055713) | 3055713..3056273 | + | 561 | Protein_2946 | DUF4942 domain-containing protein | - |
| CPZ98_RS15340 (3056345) | 3056345..3057349 | + | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| CPZ98_RS15345 (3057631) | 3057631..3057912 | + | 282 | Protein_2948 | DUF4942 domain-containing protein | - |
| CPZ98_RS15355 (3058384) | 3058384..3059322 | + | 939 | Protein_2949 | glyoxylate/hydroxypyruvate reductase GhrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | csgG / csgF / csgE / csgD / csgB / csgA / csgC | 3032880..3080937 | 48057 | |
| - | flank | IS/Tn | - | - | 3050219..3050722 | 503 | |
| - | flank | IS/Tn | - | - | 3056345..3057349 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T87717 WP_000854917.1 NZ_CP024473:3054557-3054931 [Shigella flexneri 7b]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T87717 NZ_CP024473:3054557-3054931 [Shigella flexneri 7b]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT87717 WP_001280958.1 NZ_CP024473:3054136-3054510 [Shigella flexneri 7b]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT87717 NZ_CP024473:3054136-3054510 [Shigella flexneri 7b]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |