Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 412572..413226 Replicon chromosome
Accession NZ_CP024473
Organism Shigella flexneri 7b strain 94-3007

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag CPZ98_RS02030 Protein ID WP_000244767.1
Coordinates 412572..412979 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag CPZ98_RS02035 Protein ID WP_000354044.1
Coordinates 412960..413226 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ98_RS02010 (408529) 408529..410262 - 1734 WP_130862165.1 single-stranded-DNA-specific exonuclease RecJ -
CPZ98_RS02015 (410268) 410268..410978 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CPZ98_RS02020 (411003) 411003..411899 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
CPZ98_RS02025 (412011) 412011..412532 + 522 WP_001055867.1 flavodoxin FldB -
CPZ98_RS02030 (412572) 412572..412979 - 408 WP_000244767.1 protein YgfX Toxin
CPZ98_RS02035 (412960) 412960..413226 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
CPZ98_RS02040 (413469) 413469..414449 + 981 WP_000886065.1 tRNA-modifying protein YgfZ -
CPZ98_RS02045 (414645) 414645..415304 - 660 WP_000250274.1 hemolysin III family protein -
CPZ98_RS02050 (415468) 415468..415778 - 311 Protein_389 N(4)-acetylcytidine aminohydrolase -
CPZ98_RS02055 (415823) 415823..417256 + 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
CPZ98_RS02060 (417313) 417313..418055 - 743 Protein_391 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T87708 WP_000244767.1 NZ_CP024473:c412979-412572 [Shigella flexneri 7b]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T87708 NZ_CP024473:c412979-412572 [Shigella flexneri 7b]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT87708 WP_000354044.1 NZ_CP024473:c413226-412960 [Shigella flexneri 7b]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87708 NZ_CP024473:c413226-412960 [Shigella flexneri 7b]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References