Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 136092..136651 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP024469 | ||
| Organism | Shigella dysenteriae strain BU53M1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q327A7 |
| Locus tag | CPZ97_RS26275 | Protein ID | WP_000421263.1 |
| Coordinates | 136376..136651 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q327A8 |
| Locus tag | CPZ97_RS26270 | Protein ID | WP_001178088.1 |
| Coordinates | 136092..136376 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ97_RS26220 | 131183..131880 | - | 698 | Protein_154 | IS1 family transposase | - |
| CPZ97_RS26225 | 131936..132336 | - | 401 | Protein_155 | transposase | - |
| CPZ97_RS27940 | 132401..132541 | - | 141 | Protein_156 | IS3 family transposase | - |
| CPZ97_RS26230 | 132596..133129 | - | 534 | Protein_157 | transposase | - |
| CPZ97_RS27945 | 133244..133882 | - | 639 | WP_000607008.1 | type III secretion system effector OspI | - |
| CPZ97_RS26240 | 134041..134510 | - | 470 | Protein_159 | IS1 family transposase | - |
| CPZ97_RS26250 | 134846..135031 | + | 186 | Protein_160 | ATP-binding protein | - |
| CPZ97_RS26255 | 135131..135340 | - | 210 | Protein_161 | peptidoglycan-binding protein | - |
| CPZ97_RS26270 | 136092..136376 | + | 285 | WP_001178088.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| CPZ97_RS26275 | 136376..136651 | + | 276 | WP_000421263.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CPZ97_RS27950 | 136783..136920 | - | 138 | WP_000766699.1 | hypothetical protein | - |
| CPZ97_RS26280 | 137012..137377 | - | 366 | WP_000361390.1 | plasmid partitioning/stability family protein | - |
| CPZ97_RS26285 | 137380..137948 | - | 569 | Protein_166 | plasmid segregation protein ParM | - |
| CPZ97_RS26290 | 137956..139046 | + | 1091 | Protein_167 | IS66 family transposase | - |
| CPZ97_RS26295 | 139422..140115 | - | 694 | Protein_168 | IS1 family transposase | - |
| CPZ97_RS26300 | 140355..140573 | + | 219 | WP_000813626.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| CPZ97_RS26305 | 140575..140880 | + | 306 | WP_001159860.1 | type II toxin-antitoxin system toxin CcdB | - |
| CPZ97_RS26310 | 140904..141011 | + | 108 | WP_023592908.1 | transposase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / nleE / icsP/sopA / ospB / ospC2 / ospD2 / ospF / ospD1 / ipgB2 / ipaH4.5 / ipaH7.8 / ipaH1.4 / ospE2 / ospC1 / ospD3/senA / ospC2 / ospI / ipaH9.8 / ospG / ospC3 | 1..184894 | 184894 | |
| - | inside | IScluster/Tn | - | ipaH1.4 / ospE2 / ospC1 / ospD3/senA / ospC2 / ospI / ipaH9.8 / ospG | 102485..147034 | 44549 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10792.51 Da Isoelectric Point: 9.8135
>T87704 WP_000421263.1 NZ_CP024469:136376-136651 [Shigella dysenteriae]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFTGEYEIRYELTGQTIY
VLRLWYTRENR
Download Length: 276 bp
>T87704 NZ_CP024469:136376-136651 [Shigella dysenteriae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTAGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCGCCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTACTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGTACACACGAGAGAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10497.93 Da Isoelectric Point: 6.2150
>AT87704 WP_001178088.1 NZ_CP024469:136092-136376 [Shigella dysenteriae]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDHPLPVPR
Download Length: 285 bp
>AT87704 NZ_CP024469:136092-136376 [Shigella dysenteriae]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAAGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACCATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|